GEA2 Arf family guanine nucleotide exchange factor GEA2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GEA2
Official Full Name: Arf family guanine nucleotide exchange factor GEA2
Primary source: SGD:S000000748
Locus tag: YEL022W
See related: AllianceGenome:SGD:S000000748; FungiDB:YEL022W; VEuPathDB:YEL022W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including Golgi vesicle transport; macroautophagy; and secretory granule organization. Located in Golgi cis cisterna. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate A. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GEA2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (111421..115800)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for activation of Arf1 at the Golgi complex.
Title: Structural basis for activation of Arf1 at the Golgi complex.
results demonstrate that activated Arl1p can promote the spatial modulation of membrane organization at the trans-Golgi network through interacting with the effectors Gea2p and Drs2p
Title: Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p.
basic residues required for phosphoinositide binding overlap a previously mapped binding site for the ArfGEF Gea2p.
Title: Regulation of a Golgi flippase by phosphoinositides and an ArfGEF.
COPI in these mutants is released from Golgi membranes by brefeldin A, a drug that binds directly to Gea2p and blocks ADP-ribosylation factor activation
Title: Mutations in a highly conserved region of the Arf1p activator GEA2 block anterograde Golgi transport but not COPI recruitment to membranes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1248 (e-PCR)
- UniSTS:149861

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IGI Inferred from Genetic Interaction more info	PubMed
involved_in secretory granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi cis cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Arf family guanine nucleotide exchange factor GEA2

NP_010892.1

Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

111421..115800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178837.1 → NP_010892.1 TPA: Arf family guanine nucleotide exchange factor GEA2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010892.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLM6, P39993

UniProtKB/TrEMBL

C7GX20, C8Z6X4, N1PA75

Conserved Domains (1) summary

COG5307
Location:298 → 1331

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]