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    PSY2 Psy2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855520, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PSY2
    Official Full Name
    Psy2p
    Primary source
    SGD:S000005145
    Locus tag
    YNL201C
    See related
    AllianceGenome:SGD:S000005145; FungiDB:YNL201C; VEuPathDB:YNL201C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein phosphatase regulator activity. Involved in several processes, including negative regulation of glucose mediated signaling pathway; positive regulation of double-strand break repair via nonhomologous end joining; and regulation of cell cycle phase transition. Located in nucleus. Part of protein phosphatase 4 complex. Orthologous to human PPP4R3A (protein phosphatase 4 regulatory subunit 3A); PPP4R3B (protein phosphatase 4 regulatory subunit 3B); and PPP4R3C (protein phosphatase 4 regulatory subunit 3C). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PSY2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (260627..263203, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sps18p Neighboring gene 2,4-dienoyl-CoA reductase (NADPH) Neighboring gene NADHX epimerase Neighboring gene Gcr2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide identification of genes conferring resistance to the anticancer agents cisplatin, oxaliplatin, and mitomycin C. Wu HI, et al. Cancer Res, 2004 Jun 1. PMID 15173006
    2. The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin. Hastie CJ, et al. FEBS J, 2006 Jul. PMID 16857015
    3. Exploring a Local Genetic Interaction Network Using Evolutionary Replay Experiments. Vignogna RC, et al. Mol Biol Evol, 2021 Jul 29. PMID 33749796, Free PMC Article
    4. Meiotic DNA double-strand break-independent role of protein phosphatase 4 in Hop1 assembly to promote meiotic chromosome axis formation in budding yeast. Li K, et al. Genes Cells, 2023 Aug. PMID 37243502
    5. Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling. Hustedt N, et al. Mol Cell, 2015 Jan 22. PMID 25533186, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Physical interaction between Pph3 and Mec1, mediated by cofactors Psy2 and Ddc2, is important for regulating the checkpoint response in yeast.
      Title: Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.
    2. Data indicate that the phosphatase complex Pph3/Psy2 connects homologous end-joining (NHEJ) repair to cell cycle progression.
      Title: Phosphatase complex Pph3/Psy2 is involved in regulation of efficient non-homologous end-joining pathway in the yeast Saccharomyces cerevisiae.
    3. Data show that Pph3-Psy2 targets the glucose signal transducer protein Mth1, which is required for the dephosphorylation of Rgt1 upon glucose withdrawal, a critical event in the repression of HXT genes, which encode glucose transporters.
      Title: Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression.
    4. Results suggest that the trimeric Pph3p-Psy4p-Psy2p complex may dephosphorylate both gammaH2AX and Rad53p.
      Title: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage.
    5. Involement of PSY2 in the DNA damage response.
      Title: Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response.
    6. Rad53 regulates replication fork restart and initiation of late firing origins independently
      Title: Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic recombination checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of glucose mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase 4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase 4 complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Psy2p
    NP_014198.1
    • Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      260627..263203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183039.1 → NP_014198.1  TPA: Psy2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014198.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Y7, P40164
      UniProtKB/TrEMBL
      G2WLR0, N1NWF0
      Conserved Domains (1) summary
      pfam04802
      Location:193 → 392
      SMK-1; Component of IIS longevity pathway SMK-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40164.1

    Gene LinkOut

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