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    RTKN rhotekin [ Canis lupus familiaris (dog) ]

    Gene ID: 475788, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RTKNprovided by VGNC
    Official Full Name
    rhotekinprovided by VGNC
    Primary source
    VGNC:VGNC:45789
    See related
    Ensembl:ENSCAFG00845019489
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See RTKN in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (49544030..49559627)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (48326399..48341970)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (49185611..49201210)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (48561122..48576674)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (48627658..48643209)

    Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 1 Neighboring gene INO80 complex subunit B Neighboring gene chromosome 17 C2orf81 homolog Neighboring gene WD repeat domain 54 Neighboring gene dynactin subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in septin ring organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actomyosin contractile ring IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rhotekin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051821.1 Reference ROS_Cfam_1.0

      Range
      49544030..49559627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038691685.1 → XP_038547613.1  rhotekin isoform X3

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QHH3, A0A8C0QNA5, A0A8I3PH15
      Related
      ENSCAFP00845026926.1, ENSCAFT00845034389.1
      Conserved Domains (3) summary
      smart00742
      Location:37 → 91
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:309 → 419
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:117 → 270
      Anillin; Cell division protein anillin

    2. XM_038691690.1 → XP_038547618.1  rhotekin isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QNA5
      Conserved Domains (3) summary
      cd13249
      Location:259 → 369
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    3. XM_038691686.1 → XP_038547614.1  rhotekin isoform X4

      UniProtKB/TrEMBL
      A0A8C0KMQ9, A0A8C0NW34, A0A8C0PA49, A0A8C0QNA5, A0A8I3PH73
      Related
      ENSCAFP00845026998.1, ENSCAFT00845034471.1
      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:296 → 406
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin

    4. XM_038691687.1 → XP_038547615.1  rhotekin isoform X4

      UniProtKB/TrEMBL
      A0A8C0KMQ9, A0A8C0NW34, A0A8C0PA49, A0A8C0QNA5, A0A8I3PH73
      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:296 → 406
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin

    5. XM_038691689.1 → XP_038547617.1  rhotekin isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QNA5
      Conserved Domains (3) summary
      cd13249
      Location:259 → 369
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    6. XM_038691688.1 → XP_038547616.1  rhotekin isoform X5

      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    7. XM_038691684.1 → XP_038547612.1  rhotekin isoform X2

      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    8. XM_038691683.1 → XP_038547611.1  rhotekin isoform X1

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QNA5
      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049277.1 Alternate UMICH_Zoey_3.1

      Range
      48561122..48576674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038499126.1 → XP_038355054.1  rhotekin isoform X3

      Conserved Domains (3) summary
      smart00742
      Location:37 → 91
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:309 → 419
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:117 → 270
      Anillin; Cell division protein anillin

    2. XM_038499131.1 → XP_038355059.1  rhotekin isoform X6

      Conserved Domains (3) summary
      cd13249
      Location:259 → 369
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    3. XM_038499127.1 → XP_038355055.1  rhotekin isoform X4

      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:296 → 406
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin

    4. XM_038499128.1 → XP_038355056.1  rhotekin isoform X4

      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:296 → 406
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin

    5. XM_038499130.1 → XP_038355058.1  rhotekin isoform X6

      Conserved Domains (3) summary
      cd13249
      Location:259 → 369
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    6. XM_038499129.1 → XP_038355057.1  rhotekin isoform X5

      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    7. XM_038499125.1 → XP_038355053.1  rhotekin isoform X2

      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    8. XM_038499124.1 → XP_038355052.1  rhotekin isoform X1

      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

      Range
      48627658..48643209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038625755.1 → XP_038481683.1  rhotekin isoform X3

    2. XM_038625760.1 → XP_038481688.1  rhotekin isoform X6

    3. XM_038625756.1 → XP_038481684.1  rhotekin isoform X4

    4. XM_038625757.1 → XP_038481685.1  rhotekin isoform X4

    5. XM_038625759.1 → XP_038481687.1  rhotekin isoform X6

    6. XM_038625758.1 → XP_038481686.1  rhotekin isoform X5

    7. XM_038625754.1 → XP_038481682.1  rhotekin isoform X2

    8. XM_038625753.1 → XP_038481681.1  rhotekin isoform X1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

      Range
      49185611..49201210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038561713.1 → XP_038417641.1  rhotekin isoform X3

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QHH3, A0A8C0QNA5, A0A8I3PH15
      Conserved Domains (3) summary
      smart00742
      Location:37 → 91
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:309 → 419
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:117 → 270
      Anillin; Cell division protein anillin

    2. XM_038561718.1 → XP_038417646.1  rhotekin isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QNA5
      Conserved Domains (3) summary
      cd13249
      Location:259 → 369
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    3. XM_038561714.1 → XP_038417642.1  rhotekin isoform X4

      UniProtKB/TrEMBL
      A0A8C0KMQ9, A0A8C0NW34, A0A8C0PA49, A0A8C0QNA5, A0A8I3PH73
      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:296 → 406
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin

    4. XM_038561715.1 → XP_038417643.1  rhotekin isoform X4

      UniProtKB/TrEMBL
      A0A8C0KMQ9, A0A8C0NW34, A0A8C0PA49, A0A8C0QNA5, A0A8I3PH73
      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:296 → 406
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin

    5. XM_038561717.1 → XP_038417645.1  rhotekin isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QNA5
      Conserved Domains (3) summary
      cd13249
      Location:259 → 369
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    6. XM_038561716.1 → XP_038417644.1  rhotekin isoform X5

      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    7. XM_038561712.1 → XP_038417640.1  rhotekin isoform X2

      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    8. XM_038561711.1 → XP_038417639.1  rhotekin isoform X1

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QNA5
      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      48326399..48341970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_532998.7 → XP_532998.2  rhotekin isoform X3

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QHH3, A0A8C0QNA5, A0A8I3PH15
      Conserved Domains (3) summary
      smart00742
      Location:37 → 91
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:309 → 419
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:117 → 270
      Anillin; Cell division protein anillin

    2. XM_038453461.1 → XP_038309389.1  rhotekin isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QNA5
      Conserved Domains (3) summary
      cd13249
      Location:259 → 369
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    3. XM_861062.6 → XP_866155.1  rhotekin isoform X4

      UniProtKB/TrEMBL
      A0A8C0KMQ9, A0A8C0NW34, A0A8C0PA49, A0A8C0QNA5, A0A8I3PH73
      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:296 → 406
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin

    4. XM_022404803.2 → XP_022260511.1  rhotekin isoform X4

      UniProtKB/TrEMBL
      A0A8C0KMQ9, A0A8C0NW34, A0A8C0PA49, A0A8C0QNA5, A0A8I3PH73
      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:296 → 406
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin

    5. XM_014120285.3 → XP_013975760.1  rhotekin isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QNA5
      Conserved Domains (3) summary
      cd13249
      Location:259 → 369
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    6. XM_005630535.4 → XP_005630592.2  rhotekin isoform X5

      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    7. XM_038453460.1 → XP_038309388.1  rhotekin isoform X2

      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin

    8. XM_005630534.4 → XP_005630591.2  rhotekin isoform X1

      UniProtKB/TrEMBL
      A0A8C0NW34, A0A8C0QNA5
      Conserved Domains (3) summary
      smart00742
      Location:9 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:88 → 241
      Anillin; Cell division protein anillin
    Nucleotide Protein
    Heading Accession and Version

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