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    MYLK myosin light chain kinase [ Homo sapiens (human) ]

    Gene ID: 4638, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MYLKprovided by HGNC
    Official Full Name
    myosin light chain kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:7590
    See related
    Ensembl:ENSG00000065534 MIM:600922; AllianceGenome:HGNC:7590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KRP; AAT7; MLCK; MLCK1; MMIHS; MYLK1; MMIHS1; MYLK-L; smMLCK; MLCK108; MLCK210; MSTP083
    Summary
    This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in prostate (RPKM 187.5), endometrium (RPKM 154.5) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYLK in Genome Data Viewer
    Location:
    3q21.1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (123610049..123884332, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (126330173..126610461, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123328896..123603179, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123104604-123105104 Neighboring gene uncharacterized LOC124909420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123105105-123105605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123130683-123131208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:123132020-123132563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:123166099-123166998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123178428-123178928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123178929-123179429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14647 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20393 Neighboring gene MPRA-validated peak4801 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20394 Neighboring gene MYLK antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:123347871-123349070 Neighboring gene Sharpr-MPRA regulatory region 9008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123354794-123355455 Neighboring gene uncharacterized LOC124909421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123368429-123368930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123368931-123369430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123372559-123373059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123401333-123402150 Neighboring gene uncharacterized LOC105369194 Neighboring gene MYLK antisense RNA 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:123511339-123512538 Neighboring gene Sharpr-MPRA regulatory region 10510 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene MPRA-validated peak4802 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14650 Neighboring gene coiled-coil domain containing 14 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:123680084-123680394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123699087-123699586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123710743-123711259 Neighboring gene rhophilin associated tail protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. Clayburgh DR, et al. J Biol Chem, 2004 Dec 31. PMID 15507455, Free PMC Article
    2. MYLK pathogenic variants aortic disease presentation, pregnancy risk, and characterization of pathogenic missense variants. Wallace SE, et al. Genet Med, 2019 Jan. PMID 29925964, Free PMC Article
    3. Fatal thoracic aortic aneurysm and dissection in a large family with a novel MYLK gene mutation: delineation of the clinical phenotype. Shalata A, et al. Orphanet J Rare Dis, 2018 Mar 15. PMID 29544503, Free PMC Article
    4. Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cells. Geguchadze R, et al. FEBS Lett, 2004 Jan 16. PMID 14741352
    5. Loss-of-Function Variants in MYLK Cause Recessive Megacystis Microcolon Intestinal Hypoperistalsis Syndrome. Halim D, et al. Am J Hum Genet, 2017 Jul 6. PMID 28602422, Free PMC Article

    See all (172) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation.
      Title: The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation.
    2. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.
      Title: Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.
    3. The m(6)A methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression.
      Title: The m(6)A methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression.
    4. SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
      Title: SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
    5. CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.
      Title: CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.
    6. Procyanidin A1 and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway.
      Title: Procyanidin A(1) and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway.
    7. Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis.
      Title: Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis.
    8. CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
      Title: CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
    9. A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
      Title: A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
    10. Silencing of long noncoding RNA MYLK-AS1 suppresses nephroblastoma via down-regulation of CCNE1 through transcription factor TCF7L2.
      Title: Silencing of long noncoding RNA MYLK-AS1 suppresses nephroblastoma via down-regulation of CCNE1 through transcription factor TCF7L2.
    Submit: New GeneRIF Correction See all GeneRIFs (98)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MYLK that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2016-01-14)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2016-01-14)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat in combination with morphine activates myosin light chain kinase expression in primary brain micro vascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12216, DKFZp686I10125

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin light chain kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin light chain kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aorta smooth muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bleb assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hypotonic response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tonic smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tonic smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin light chain kinase, smooth muscle
    Names
    kinase-related protein
    myosin, light polypeptide kinase
    smooth muscle myosin light chain kinase
    telokin
    NP_001308238.1
    NP_444253.3
    NP_444254.3
    NP_444255.3
    NP_444256.3
    NP_444259.1
    NP_444260.1
    XP_011511162.2
    XP_011511163.2
    XP_016861958.2
    XP_016861959.1
    XP_016861960.1
    XP_016861961.1
    XP_016861962.1
    XP_024309300.1
    XP_024309302.1
    XP_024309305.1
    XP_047304138.1
    XP_047304139.1
    XP_047304140.1
    XP_047304141.1
    XP_047304142.1
    XP_047304143.1
    XP_047304144.1
    XP_054202587.1
    XP_054202588.1
    XP_054202589.1
    XP_054202590.1
    XP_054202591.1
    XP_054202592.1
    XP_054202593.1
    XP_054202594.1
    XP_054202595.1
    XP_054202596.1
    XP_054202597.1
    XP_054202598.1
    XP_054202599.1
    XP_054202600.1
    XP_054202601.1
    XP_054202602.1
    XP_054202603.1
    XP_054202604.1
    XP_054202605.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029111.2 RefSeqGene

      Range
      5000..279283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321309.2 → NP_001308238.1  myosin light chain kinase, smooth muscle isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064695, BC113458, BQ006428, DA853780, U48959
      UniProtKB/TrEMBL
      A0A8I5QKL9
      Conserved Domains (9) summary
      cd00096
      Location:464 → 533
      Ig; Immunoglobulin domain
      cd05762
      Location:1062 → 1159
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:1646 → 1713
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:1155 → 1247
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1633 → 1723
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1285 → 1543
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:1288 → 1543
      Pkinase; Protein kinase domain
      pfam16620
      Location:75 → 236
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:548 → 633
      Ig; Immunoglobulin domain

    2. NM_053025.4 → NP_444253.3  myosin light chain kinase, smooth muscle isoform 1

      See identical proteins and their annotated locations for NP_444253.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the full-length transcript and encodes the full-length nonmuscle isoform.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS46896.1
      UniProtKB/Swiss-Prot
      B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9
      UniProtKB/TrEMBL
      A0A8I5QKL9
      Related
      ENSP00000353452.3, ENST00000360304.8
      Conserved Domains (5) summary
      cd05762
      Location:1238 → 1335
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:1331 → 1423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1809 → 1899
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1461 → 1719
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251 → 412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

    3. NM_053026.4 → NP_444254.3  myosin light chain kinase, smooth muscle isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) does not utilize exon 11, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS43141.1
      UniProtKB/TrEMBL
      A0A8I5QKL9
      Related
      ENSP00000510503.1, ENST00000693689.1
      Conserved Domains (5) summary
      cd05762
      Location:1169 → 1266
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:1262 → 1354
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1740 → 1830
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1392 → 1650
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251 → 412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

    4. NM_053027.4 → NP_444255.3  myosin light chain kinase, smooth muscle isoform 3A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3A) does not utilize exon 30, compared to variant 1, resulting in a shorter protein (isoform 3A), compared to isoform 1.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS3023.1
      UniProtKB/TrEMBL
      A0A8I5QKL9
      Related
      ENSP00000354004.3, ENST00000360772.7
      Conserved Domains (9) summary
      cd00096
      Location:640 → 709
      Ig; Immunoglobulin domain
      cd05762
      Location:1238 → 1335
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:1771 → 1838
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:1331 → 1423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1758 → 1848
      I-set; Immunoglobulin I-set domain
      pfam00069
      Location:1464 → 1668
      Pkinase; Protein kinase domain
      pfam16620
      Location:251 → 412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:724 → 809
      Ig; Immunoglobulin domain
      cl21453
      Location:1461 → 1668
      PKc_like; Protein Kinases, catalytic domain

    5. NM_053028.4 → NP_444256.3  myosin light chain kinase, smooth muscle isoform 3B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3B) does not utilize exons 11 and 30, compared to variant 1, resulting in a shorter protein (isoform 3B), compared to isoform 1.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS93356.1
      UniProtKB/TrEMBL
      A0A8I5QKL9
      Related
      ENSP00000320622.6, ENST00000346322.10
      Conserved Domains (9) summary
      cd00096
      Location:571 → 640
      Ig; Immunoglobulin domain
      cd05762
      Location:1169 → 1266
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:1702 → 1769
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:1262 → 1354
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1689 → 1779
      I-set; Immunoglobulin I-set domain
      pfam00069
      Location:1395 → 1599
      Pkinase; Protein kinase domain
      pfam16620
      Location:251 → 412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:655 → 740
      Ig; Immunoglobulin domain
      cl21453
      Location:1392 → 1599
      PKc_like; Protein Kinases, catalytic domain

    6. NM_053031.4 → NP_444259.1  myosin light chain kinase, smooth muscle isoform 7

      See identical proteins and their annotated locations for NP_444259.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes the shorter isoform of kinase related protein, telokin. The first exon corresponds to intron 30 and the remainder of the transcript corresponds to the last two exons of the gene. It is shorter than variant 8 by one codon at the splicing junction between the first two exons.
      Source sequence(s)
      AC023165, BC064420, BC113458, DB016380
      Consensus CDS
      CCDS58849.1
      UniProtKB/TrEMBL
      Q05B97
      Related
      ENSP00000510047.1, ENST00000685744.1
      Conserved Domains (1) summary
      cd20973
      Location:51 → 138
      IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

    7. NM_053032.4 → NP_444260.1  myosin light chain kinase, smooth muscle isoform 8

      See identical proteins and their annotated locations for NP_444260.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes the longer isoform of kinase related protein, telokin. It is longer than variant 7 by one codon at the splicing junction between the first two exons.
      Source sequence(s)
      AC023165, BC064420, BC113456, DB016380
      Consensus CDS
      CCDS46897.1
      UniProtKB/TrEMBL
      Q05B97
      Related
      ENSP00000428967.1, ENST00000418370.6
      Conserved Domains (1) summary
      cd20973
      Location:52 → 139
      IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      123610049..123884332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448184.1 → XP_047304140.1  myosin light chain kinase, smooth muscle isoform X7

      UniProtKB/Swiss-Prot
      B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9

    2. XM_024453532.2 → XP_024309300.1  myosin light chain kinase, smooth muscle isoform X6

      UniProtKB/TrEMBL
      A0A8I5KU53, A0A8I5QKL9
      Related
      ENSP00000508761.1, ENST00000687848.1
      Conserved Domains (5) summary
      cd05762
      Location:1248 → 1345
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:1341 → 1433
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1819 → 1909
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1471 → 1729
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:261 → 422
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

    3. XM_047448183.1 → XP_047304139.1  myosin light chain kinase, smooth muscle isoform X6

      UniProtKB/TrEMBL
      A0A8I5KU53

    4. XM_047448187.1 → XP_047304143.1  myosin light chain kinase, smooth muscle isoform X6

      UniProtKB/TrEMBL
      A0A8I5KU53

    5. XM_047448186.1 → XP_047304142.1  myosin light chain kinase, smooth muscle isoform X8

    6. XM_017006469.3 → XP_016861958.2  myosin light chain kinase, smooth muscle isoform X5

    7. XM_024453534.2 → XP_024309302.1  myosin light chain kinase, smooth muscle isoform X3

      UniProtKB/TrEMBL
      A0A8I5QKL9
      Related
      ENSP00000508777.1, ENST00000690457.1
      Conserved Domains (5) summary
      cd05762
      Location:1179 → 1276
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:1272 → 1364
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1750 → 1840
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1402 → 1660
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:261 → 422
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

    8. XM_047448182.1 → XP_047304138.1  myosin light chain kinase, smooth muscle isoform X4

    9. XM_011512861.4 → XP_011511163.2  myosin light chain kinase, smooth muscle isoform X2

      UniProtKB/TrEMBL
      A0A8I5QKL9
      Conserved Domains (5) summary
      cd05762
      Location:1248 → 1345
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:1341 → 1433
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1751 → 1841
      I-set; Immunoglobulin I-set domain
      pfam16620
      Location:261 → 422
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl21453
      Location:1483 → 1661
      PKc_like; Protein Kinases, catalytic domain

    10. XM_011512860.4 → XP_011511162.2  myosin light chain kinase, smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A8I5QKL9
      Conserved Domains (5) summary
      cd05762
      Location:1248 → 1345
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:1341 → 1433
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1818 → 1908
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1471 → 1729
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:261 → 422
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

    11. XM_024453537.2 → XP_024309305.1  myosin light chain kinase, smooth muscle isoform X7

      UniProtKB/Swiss-Prot
      B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9
      UniProtKB/TrEMBL
      A0A8I5QKL9
      Related
      ENSP00000508758.1, ENST00000686761.1
      Conserved Domains (5) summary
      cd05762
      Location:1238 → 1335
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:1331 → 1423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1809 → 1899
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1461 → 1719
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251 → 412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

    12. XM_047448185.1 → XP_047304141.1  myosin light chain kinase, smooth muscle isoform X7

      UniProtKB/Swiss-Prot
      B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9

    13. XM_047448188.1 → XP_047304144.1  myosin light chain kinase, smooth muscle isoform X11

    14. XM_017006470.3 → XP_016861959.1  myosin light chain kinase, smooth muscle isoform X10

      UniProtKB/TrEMBL
      A0A8I5KTQ1
      Related
      ENSP00000510593.1, ENST00000685953.1

    15. XM_017006471.3 → XP_016861960.1  myosin light chain kinase, smooth muscle isoform X9

      UniProtKB/Swiss-Prot
      Q15746
      Related
      ENSP00000422984.2, ENST00000508240.2
      Conserved Domains (4) summary
      cd00063
      Location:131 → 223
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05762
      Location:37 → 135
      IgI_8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar protein; member of the I-set of IgSF domains
      cd20973
      Location:612 → 699
      IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains
      cl21453
      Location:261 → 519
      PKc_like; Protein Kinases, catalytic domain

    16. XM_017006473.2 → XP_016861962.1  myosin light chain kinase, smooth muscle isoform X13

      UniProtKB/TrEMBL
      Q05B97
      Related
      ENSP00000509867.1, ENST00000687375.1
      Conserved Domains (1) summary
      cd20973
      Location:51 → 138
      IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

    17. XM_017006472.3 → XP_016861961.1  myosin light chain kinase, smooth muscle isoform X12

      UniProtKB/TrEMBL
      Q05B97
      Related
      ENSP00000462118.1, ENST00000583087.6
      Conserved Domains (1) summary
      cd20973
      Location:52 → 139
      IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      126330173..126610461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346621.1 → XP_054202596.1  myosin light chain kinase, smooth muscle isoform X7

    2. XM_054346619.1 → XP_054202594.1  myosin light chain kinase, smooth muscle isoform X6

    3. XM_054346625.1 → XP_054202600.1  myosin light chain kinase, smooth muscle isoform X6

    4. XM_054346616.1 → XP_054202591.1  myosin light chain kinase, smooth muscle isoform X4

    5. XM_054346614.1 → XP_054202589.1  myosin light chain kinase, smooth muscle isoform X2

    6. XM_054346612.1 → XP_054202587.1  myosin light chain kinase, smooth muscle isoform X1

    7. XM_054346624.1 → XP_054202599.1  myosin light chain kinase, smooth muscle isoform X8

    8. XM_054346617.1 → XP_054202592.1  myosin light chain kinase, smooth muscle isoform X5

    9. XM_054346613.1 → XP_054202588.1  myosin light chain kinase, smooth muscle isoform X7

    10. XM_054346618.1 → XP_054202593.1  myosin light chain kinase, smooth muscle isoform X14

    11. XM_054346615.1 → XP_054202590.1  myosin light chain kinase, smooth muscle isoform X3

    12. XM_054346622.1 → XP_054202597.1  myosin light chain kinase, smooth muscle isoform X7

    13. XM_054346620.1 → XP_054202595.1  myosin light chain kinase, smooth muscle isoform X6

    14. XM_054346623.1 → XP_054202598.1  myosin light chain kinase, smooth muscle isoform X7

    15. XM_054346628.1 → XP_054202603.1  myosin light chain kinase, smooth muscle isoform X9

    16. XM_054346627.1 → XP_054202602.1  myosin light chain kinase, smooth muscle isoform X11

    17. XM_054346626.1 → XP_054202601.1  myosin light chain kinase, smooth muscle isoform X10

      UniProtKB/TrEMBL
      A0A8I5KTQ1

    18. XM_054346630.1 → XP_054202605.1  myosin light chain kinase, smooth muscle isoform X13

    19. XM_054346629.1 → XP_054202604.1  myosin light chain kinase, smooth muscle isoform X12

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005965.3: Suppressed sequence

      Description
      NM_005965.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_053029.2: Suppressed sequence

      Description
      NM_053029.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    3. NM_053030.2: Suppressed sequence

      Description
      NM_053030.2: This RefSeq was permanently suppressed because there was insufficient support for the transcript and the CDS was partial.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15746.4 GenPept UniProtKB/Swiss-Prot:Q15746

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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