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    DOCK9 dedicator of cytokinesis 9 [ Homo sapiens (human) ]

    Gene ID: 23348, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DOCK9provided by HGNC
    Official Full Name
    dedicator of cytokinesis 9provided by HGNC
    Primary source
    HGNC:HGNC:14132
    See related
    Ensembl:ENSG00000088387 MIM:607325; AllianceGenome:HGNC:14132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIZ1; ZIZIMIN1
    Summary
    Enables cadherin binding activity. Predicted to be involved in positive regulation of GTPase activity. Located in membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 21.7), thyroid (RPKM 20.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DOCK9 in Genome Data Viewer
    Location:
    13q32.3
    Exon count:
    63
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (98793429..99088619, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (98003332..98298312, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99445683..99738948, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5461 Neighboring gene solute carrier family 15 member 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:99390337-99390879 Neighboring gene uncharacterized LOC105370330 Neighboring gene Sharpr-MPRA regulatory region 1899 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:99437954-99439153 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:99459441-99460640 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:99473100-99473600 Neighboring gene DOCK9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7923 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:99553940-99555139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99582088-99582640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99582641-99583193 Neighboring gene RPL7L1 pseudogene 12 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:99644283-99645482 Neighboring gene NANOG hESC enhancer GRCh37_chr13:99646324-99646825 Neighboring gene RNA, U6 small nuclear 83, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:99719017-99720216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5462 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:99738979-99739540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5465 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:99740103-99740662 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:99752082-99752247 Neighboring gene DOCK9 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5467 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_33558 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:99811198-99812397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:99824919-99825420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:99833707-99834219 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 22 Neighboring gene ribosomal protein S6 pseudogene 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Sequence variation in DOCK9 and heterogeneity in bipolar disorder. Detera-Wadleigh SD, et al. Psychiatr Genet, 2007 Oct. PMID 17728666
    2. Variant c.2262A>C in DOCK9 Leads to Exon Skipping in Keratoconus Family. Karolak JA, et al. Invest Ophthalmol Vis Sci, 2015 Dec. PMID 26641546
    3. Snapshots form a big picture of guanine nucleotide exchange. Rittinger K. Sci Signal, 2009 Oct 6. PMID 19809089
    4. Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Yang J, et al. Science, 2009 Sep 11. PMID 19745154
    5. Function of the N-terminus of zizimin1: autoinhibition and membrane targeting. Meller N, et al. Biochem J, 2008 Jan 15. PMID 17935486, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.
      Title: Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.
    2. c.2262A>C substitution in DOCK9 leads to a splicing aberration. However, because the mutation effect was observed in vitro, a definitive relationship between DOCK9 and KTCN phenotype could not be established.
      Title: Variant c.2262A>C in DOCK9 Leads to Exon Skipping in Keratoconus Family.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Studies indicate that that many of the mechanistic principles of the exchange process are conserved in the DOCK9-catalyzed reaction.
      Title: Snapshots form a big picture of guanine nucleotide exchange.
    5. through structural analysis of DOCK9-Cdc42 complexes, we identify a nucleotide sensor within the alpha10 helix of the DHR2 domain that contributes to release of guanine diphosphate (GDP) and then to discharge of the activated GTP-bound Cdc42
      Title: Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
    6. interaction between Smad2/3 and the Cdc42 guanine nucleotide exchange factor, Zizimin1, in response to TGF-beta1
      Title: Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1.
    7. DOCK2 and DOCK9 specifically recognize Rac2 and Cdc42 through their switch 1 as well as beta2-beta3 regions and the mode of recognition via switch 1 appears to be conserved among diverse Rac-specific DHR-2 GEFs
      Title: Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Sequence variation in DOCK9 and heterogeneity in bipolar disorder.
    9. novel functions for the N-terminal region of zizimin1.
      Title: Function of the N-terminus of zizimin1: autoinhibition and membrane targeting.
    10. DOCK9 contributes to both risk and increased illness severity in bipolar disorder.
      Title: Sequence variation in DOCK9 and heterogeneity in bipolar disorder.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11949, FLJ16744, FLJ44528, FLJ45282, FLJ45601, KIAA1058, KIAA1085, DKFZp686D2047, DKFZp686C11110, DKFZp686N04132

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 9
    Names
    cdc42 guanine nucleotide exchange factor zizimin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130048.2 → NP_001123520.1  dedicator of cytokinesis protein 9 isoform b

      See identical proteins and their annotated locations for NP_001123520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) has a distinct N-terminus that is 1 aa shorter than that of isoform a.
      Source sequence(s)
      AB028981, AK127215, AL161420, BC043506, BM968821, DB277756
      Consensus CDS
      CCDS45062.1
      UniProtKB/TrEMBL
      A0A2X0SYY4
      Related
      ENSP00000365643.1, ENST00000376460.5
      Conserved Domains (5) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1611 → 2062
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:174 → 279
      PH; PH domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    2. NM_001130049.2 → NP_001123521.1  dedicator of cytokinesis protein 9 isoform c

      See identical proteins and their annotated locations for NP_001123521.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks several exons in the 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AF527605, AL391122, AW450751, BC146814
      Consensus CDS
      CCDS76645.1
      UniProtKB/TrEMBL
      A0A0A0MT38, A6H8Z6
      Related
      ENSP00000413781.2, ENST00000427887.2
      Conserved Domains (4) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:170 → 293
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:175 → 280
      PH; PH domain
      pfam11878
      Location:63 → 154
      DUF3398; Domain of unknown function (DUF3398)

    3. NM_001130050.2 → NP_001123522.1  dedicator of cytokinesis protein 9 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 5' coding region, and 3' UTR, and lacks several exons in the 3' coding region, compared to variant 1. The resulting isoform (d) has distinct N- and C-termini, and is shorter than isoform a.
      Source sequence(s)
      AB028981, AK126492, AW450751
      Consensus CDS
      CCDS45063.1
      UniProtKB/TrEMBL
      A6H8Z6
      Related
      ENSP00000487551.1, ENST00000627024.2
      Conserved Domains (4) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:174 → 279
      PH; PH domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    4. NM_001318849.2 → NP_001305778.1  dedicator of cytokinesis protein 9 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (e) is shorter than isoform a.
      Source sequence(s)
      AF527605, AK294705, AL161420, AL391122, BC136274, BX648707
      UniProtKB/TrEMBL
      B7ZVX0, B9EG73
      Conserved Domains (4) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1612 → 2040
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:170 → 293
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:46 → 156
      DUF3398; Domain of unknown function (DUF3398)

    5. NM_001366676.2 → NP_001353605.1  dedicator of cytokinesis protein 9 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL139084, AL161420
      UniProtKB/TrEMBL
      A0A8V8TQS9
      Related
      ENSP00000515237.1, ENST00000703210.1
      Conserved Domains (4) summary
      cd08697
      Location:650 → 839
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1623 → 2051
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:74 → 165
      DUF3398; Domain of unknown function (DUF3398)

    6. NM_001366677.2 → NP_001353606.1  dedicator of cytokinesis protein 9 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL139084, AL161420
      UniProtKB/TrEMBL
      A0A088AWN3
      Conserved Domains (4) summary
      cd08697
      Location:650 → 839
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1615 → 2041
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:74 → 165
      DUF3398; Domain of unknown function (DUF3398)

    7. NM_001366678.2 → NP_001353607.1  dedicator of cytokinesis protein 9 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL139084, AL161420
      UniProtKB/TrEMBL
      A0A8V8TR95
      Related
      ENSP00000515238.1, ENST00000703211.1
      Conserved Domains (4) summary
      cd08697
      Location:650 → 839
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1623 → 2074
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:74 → 165
      DUF3398; Domain of unknown function (DUF3398)

    8. NM_001366679.2 → NP_001353608.1  dedicator of cytokinesis protein 9 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL139084, AL161420
      UniProtKB/TrEMBL
      A0A2X0SYY4
      Conserved Domains (4) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1603 → 2029
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    9. NM_001366680.2 → NP_001353609.1  dedicator of cytokinesis protein 9 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL139084, AL161420
      Consensus CDS
      CCDS91827.1
      UniProtKB/TrEMBL
      A0A2X0SYY4, X6RGR3
      Related
      ENSP00000403528.2, ENST00000449796.6
      Conserved Domains (4) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1603 → 2017
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    10. NM_001366681.2 → NP_001353610.1  dedicator of cytokinesis protein 9 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL139084, AL161420
      UniProtKB/TrEMBL
      A0A2X0SYY4
      Conserved Domains (4) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1634 → 2083
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    11. NM_001366682.2 → NP_001353611.1  dedicator of cytokinesis protein 9 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL139084, AL161420
      UniProtKB/TrEMBL
      A0A2X0SYY4
      Conserved Domains (4) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1634 → 2060
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    12. NM_001366683.2 → NP_001353612.1  dedicator of cytokinesis protein 9 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL139084, AL161420
      Consensus CDS
      CCDS91828.1
      UniProtKB/TrEMBL
      A0A2X0SYY4, A0A804HIE8
      Related
      ENSP00000507034.1, ENST00000682017.1
      Conserved Domains (4) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1634 → 2048
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    13. NM_001366684.2 → NP_001353613.1  dedicator of cytokinesis protein 9 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL139084, AL161420
      UniProtKB/TrEMBL
      A0A2X0SYY4
      Conserved Domains (4) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1634 → 2071
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    14. NM_015296.3 → NP_056111.1  dedicator of cytokinesis protein 9 isoform a

      See identical proteins and their annotated locations for NP_056111.1

      Status: VALIDATED

      Source sequence(s)
      AF527605, AK127215, AL161420, AL391122, BC043506, BM968821
      Consensus CDS
      CCDS91829.1
      UniProtKB/Swiss-Prot
      B3KX25, E9PFM9, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9BZ29, Q9UPU4
      UniProtKB/TrEMBL
      B7ZVX0
      Related
      ENSP00000498761.1, ENST00000652315.1
      Conserved Domains (5) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1612 → 2063
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:170 → 293
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:175 → 280
      PH; PH domain
      pfam11878
      Location:63 → 154
      DUF3398; Domain of unknown function (DUF3398)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      98793429..99088619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430231.1 → XP_047286187.1  dedicator of cytokinesis protein 9 isoform X12

    2. XM_005254035.4 → XP_005254092.1  dedicator of cytokinesis protein 9 isoform X27

      UniProtKB/TrEMBL
      B7ZVX0
      Conserved Domains (5) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1604 → 2018
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:170 → 293
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:175 → 280
      PH; PH domain
      pfam11878
      Location:63 → 154
      DUF3398; Domain of unknown function (DUF3398)

    3. XM_006719937.4 → XP_006720000.1  dedicator of cytokinesis protein 9 isoform X25

      UniProtKB/TrEMBL
      B7ZVX0
      Conserved Domains (5) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1612 → 2040
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:170 → 293
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:175 → 280
      PH; PH domain
      pfam11878
      Location:63 → 154
      DUF3398; Domain of unknown function (DUF3398)

    4. XM_047430235.1 → XP_047286191.1  dedicator of cytokinesis protein 9 isoform X22

    5. XM_006719931.4 → XP_006719994.1  dedicator of cytokinesis protein 9 isoform X17

      See identical proteins and their annotated locations for XP_006719994.1

      UniProtKB/TrEMBL
      B7ZVX0
      Conserved Domains (5) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1612 → 2063
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:170 → 293
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:175 → 280
      PH; PH domain
      pfam11878
      Location:63 → 154
      DUF3398; Domain of unknown function (DUF3398)

    6. XM_005254034.4 → XP_005254091.1  dedicator of cytokinesis protein 9 isoform X21

      UniProtKB/TrEMBL
      B7ZVX0
      Conserved Domains (5) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1635 → 2049
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:170 → 293
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:175 → 280
      PH; PH domain
      pfam11878
      Location:63 → 154
      DUF3398; Domain of unknown function (DUF3398)

    7. XM_047430234.1 → XP_047286190.1  dedicator of cytokinesis protein 9 isoform X15

    8. XM_006719924.3 → XP_006719987.1  dedicator of cytokinesis protein 9 isoform X9

      UniProtKB/TrEMBL
      B7ZVX0
      Conserved Domains (5) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1635 → 2086
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:170 → 293
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:175 → 280
      PH; PH domain
      pfam11878
      Location:63 → 154
      DUF3398; Domain of unknown function (DUF3398)

    9. XM_006719936.2 → XP_006719999.1  dedicator of cytokinesis protein 9 isoform X20

      UniProtKB/TrEMBL
      A0A088AWN3
      Related
      ENSP00000401958.4, ENST00000448493.7
      Conserved Domains (5) summary
      cd08697
      Location:650 → 839
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1623 → 2051
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:186 → 291
      PH; PH domain
      pfam11878
      Location:74 → 165
      DUF3398; Domain of unknown function (DUF3398)

    10. XM_047430232.1 → XP_047286188.1  dedicator of cytokinesis protein 9 isoform X13

    11. XM_006719922.2 → XP_006719985.1  dedicator of cytokinesis protein 9 isoform X5

      UniProtKB/TrEMBL
      A0A088AWN3
      Conserved Domains (5) summary
      cd08697
      Location:650 → 839
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1646 → 2097
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:186 → 291
      PH; PH domain
      pfam11878
      Location:74 → 165
      DUF3398; Domain of unknown function (DUF3398)

    12. XM_017020513.2 → XP_016876002.1  dedicator of cytokinesis protein 9 isoform X16

      UniProtKB/TrEMBL
      A0A8V8TRI9

    13. XM_017020510.2 → XP_016875999.1  dedicator of cytokinesis protein 9 isoform X11

      UniProtKB/TrEMBL
      A0A8V8TRI9

    14. XM_017020508.2 → XP_016875997.1  dedicator of cytokinesis protein 9 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TRI9

    15. XM_017020506.2 → XP_016875995.1  dedicator of cytokinesis protein 9 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TRI9

    16. XM_017020511.2 → XP_016876000.1  dedicator of cytokinesis protein 9 isoform X14

      UniProtKB/TrEMBL
      A0A8V8TRI9

    17. XM_047430230.1 → XP_047286186.1  dedicator of cytokinesis protein 9 isoform X7

    18. XM_017020507.2 → XP_016875996.1  dedicator of cytokinesis protein 9 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TRI9

    19. XM_017020505.2 → XP_016875994.1  dedicator of cytokinesis protein 9 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TRI9

    20. XM_017020504.2 → XP_016875993.1  dedicator of cytokinesis protein 9 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TRI9

    21. XM_017020503.2 → XP_016875992.1  dedicator of cytokinesis protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8V8TRI9

    22. XM_047430237.1 → XP_047286193.1  dedicator of cytokinesis protein 9 isoform X24

    23. XM_017020515.2 → XP_016876004.1  dedicator of cytokinesis protein 9 isoform X19

      UniProtKB/TrEMBL
      A0A2X0SYY4

    24. XM_047430238.1 → XP_047286194.1  dedicator of cytokinesis protein 9 isoform X26

    25. XM_047430236.1 → XP_047286192.1  dedicator of cytokinesis protein 9 isoform X23

    26. XM_006719932.2 → XP_006719995.1  dedicator of cytokinesis protein 9 isoform X18

      UniProtKB/TrEMBL
      A0A2X0SYY4
      Conserved Domains (5) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1611 → 2062
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:174 → 279
      PH; PH domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    27. XM_006719925.2 → XP_006719988.1  dedicator of cytokinesis protein 9 isoform X10

      UniProtKB/TrEMBL
      A0A2X0SYY4
      Conserved Domains (5) summary
      cd08697
      Location:638 → 827
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1634 → 2085
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:174 → 279
      PH; PH domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    28. XM_047430240.1 → XP_047286196.1  dedicator of cytokinesis protein 9 isoform X29

      Related
      ENSP00000515240.1, ENST00000703216.1

    29. XM_047430239.1 → XP_047286195.1  dedicator of cytokinesis protein 9 isoform X28

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      98003332..98298312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374362.1 → XP_054230337.1  dedicator of cytokinesis protein 9 isoform X12

    2. XM_054374377.1 → XP_054230352.1  dedicator of cytokinesis protein 9 isoform X27

    3. XM_054374375.1 → XP_054230350.1  dedicator of cytokinesis protein 9 isoform X25

    4. XM_054374372.1 → XP_054230347.1  dedicator of cytokinesis protein 9 isoform X22

    5. XM_054374367.1 → XP_054230342.1  dedicator of cytokinesis protein 9 isoform X17

    6. XM_054374371.1 → XP_054230346.1  dedicator of cytokinesis protein 9 isoform X21

    7. XM_054374365.1 → XP_054230340.1  dedicator of cytokinesis protein 9 isoform X15

    8. XM_054374359.1 → XP_054230334.1  dedicator of cytokinesis protein 9 isoform X9

    9. XM_054374370.1 → XP_054230345.1  dedicator of cytokinesis protein 9 isoform X20

    10. XM_054374363.1 → XP_054230338.1  dedicator of cytokinesis protein 9 isoform X13

    11. XM_054374355.1 → XP_054230330.1  dedicator of cytokinesis protein 9 isoform X5

    12. XM_054374366.1 → XP_054230341.1  dedicator of cytokinesis protein 9 isoform X16

    13. XM_054374361.1 → XP_054230336.1  dedicator of cytokinesis protein 9 isoform X11

    14. XM_054374358.1 → XP_054230333.1  dedicator of cytokinesis protein 9 isoform X8

    15. XM_054374354.1 → XP_054230329.1  dedicator of cytokinesis protein 9 isoform X4

    16. XM_054374364.1 → XP_054230339.1  dedicator of cytokinesis protein 9 isoform X14

    17. XM_054374357.1 → XP_054230332.1  dedicator of cytokinesis protein 9 isoform X7

    18. XM_054374356.1 → XP_054230331.1  dedicator of cytokinesis protein 9 isoform X6

    19. XM_054374353.1 → XP_054230328.1  dedicator of cytokinesis protein 9 isoform X3

    20. XM_054374352.1 → XP_054230327.1  dedicator of cytokinesis protein 9 isoform X2

    21. XM_054374351.1 → XP_054230326.1  dedicator of cytokinesis protein 9 isoform X1

    22. XM_054374374.1 → XP_054230349.1  dedicator of cytokinesis protein 9 isoform X24

    23. XM_054374369.1 → XP_054230344.1  dedicator of cytokinesis protein 9 isoform X19

    24. XM_054374376.1 → XP_054230351.1  dedicator of cytokinesis protein 9 isoform X26

    25. XM_054374373.1 → XP_054230348.1  dedicator of cytokinesis protein 9 isoform X23

    26. XM_054374368.1 → XP_054230343.1  dedicator of cytokinesis protein 9 isoform X18

    27. XM_054374360.1 → XP_054230335.1  dedicator of cytokinesis protein 9 isoform X10

    28. XM_054374378.1 → XP_054230353.1  dedicator of cytokinesis protein 9 isoform X28

    29. XM_054374379.1 → XP_054230354.1  dedicator of cytokinesis protein 9 isoform X29

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BZ29.2 GenPept UniProtKB/Swiss-Prot:Q9BZ29

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