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    pls pyrolysin [ Pyrococcus furiosus DSM 3638 ]

    Gene ID: 1468121, updated on 22-Oct-2024

    Summary

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    Gene symbol
    pls
    Gene description
    pyrolysin
    Locus tag
    PF_RS01455
    Gene type
    protein coding
    Organism
    Pyrococcus furiosus DSM 3638 (strain: DSM 3638, type-material: type strain of Pyrococcus furiosus)
    Lineage
    Archaea; Methanobacteriati; Methanobacteriota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus
    Old locus tag
    PF0287
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    Genomic context

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    Sequence:
    NC_003413.1 (297558..301754)

    NC_003413.1Genomic Context describing neighboring genes Neighboring gene LAGLIDADG family homing endonuclease Neighboring gene tRNA-Met Neighboring gene metal-sulfur cluster assembly factor Neighboring gene phosphoenolpyruvate carboxykinase (GTP)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003413.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of metal ions on stability and activity of hyperthermophilic pyrolysin and further stabilization of this enzyme by modification of a Ca2+-binding site. Zeng J, et al. Appl Environ Microbiol, 2014 May. PMID 24561589, Free PMC Article
    2. Purification, characterization, and molecular modeling of pyrolysin and other extracellular thermostable serine proteases from hyperthermophilic microorganisms. de Vos WM, et al. Methods Enzymol, 2001. PMID 11210516
    3. Isolation and characterization of the hyperthermostable serine protease, pyrolysin, and its gene from the hyperthermophilic archaeon Pyrococcus furiosus. Voorhorst WG, et al. J Biol Chem, 1996 Aug 23. PMID 8702780
    4. Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences. Maeder DL, et al. Genetics, 1999 Aug. PMID 10430560, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Binding of Ca(2+) is important for the stabilization of pyrolysin.
      Title: Effects of metal ions on stability and activity of hyperthermophilic pyrolysin and further stabilization of this enzyme by modification of a Ca2+-binding site.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    pyrolysin
    WP_011011401.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003413.1 Reference assembly

      Range
      297558..301754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_011011401.1 pyrolysin [Pyrococcus furiosus]

      See identical proteins and their annotated locations for WP_011011401.1

      UniProtKB/Swiss-Prot
      P72186
      UniProtKB/TrEMBL
      A0A5C0XQA4, I6TUW1
      Conserved Domains (3) summary
      sd00006
      Location:1302 → 1327
      TPR; TPR repeat [structural motif]
      pfam04151
      Location:945 → 1008
      PPC; Bacterial pre-peptidase C-terminal domain
      cl10459
      Location:157 → 628
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P72186.2

    Gene LinkOut

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