CD276 CD276 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD276provided by HGNC
Official Full Name: CD276 moleculeprovided by HGNC
Primary source: HGNC:HGNC:19137
See related: Ensembl:ENSG00000103855 MIM:605715; AllianceGenome:HGNC:19137
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression: Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q24.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (73683944..73714514)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (71501041..71531847)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (73976724..74006855)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

B7-H3 promotes the migration and invasion of colorectal cancer cells via regulating the actin cytoskeleton and RhoA/ROCK1/LIMK1 signaling pathway.
Title: B7-H3 promotes the migration and invasion of colorectal cancer cells via regulating the actin cytoskeleton and RhoA/ROCK1/LIMK1 signaling pathway.
CD276 enhances sunitinib resistance in clear cell renal cell carcinoma by promoting DNA damage repair and activation of FAK-MAPK signaling pathway.
Title: CD276 enhances sunitinib resistance in clear cell renal cell carcinoma by promoting DNA damage repair and activation of FAK-MAPK signaling pathway.
CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.
Title: CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.
B7-H3 and ICAM-1 are potentially therapeutic targets for thyroid carcinoma.
Title: B7-H3 and ICAM-1 are potentially therapeutic targets for thyroid carcinoma.
Pro-cancer role of CD276 as a novel biomarker for clear cell renal cell carcinoma.
Title: Pro-cancer role of CD276 as a novel biomarker for clear cell renal cell carcinoma.
B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention.
Title: B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention.
B7-H3 is associated with the armored-cold phenotype and predicts poor immune checkpoint blockade response in melanoma.
Title: B7-H3 is associated with the armored-cold phenotype and predicts poor immune checkpoint blockade response in melanoma.
Interplay between B7-H3 and HLA class I in the clinical course of pancreatic ductal adenocarcinoma.
Title: Interplay between B7-H3 and HLA class I in the clinical course of pancreatic ductal adenocarcinoma.
B7-H3 Regulates Glucose Metabolism in Neuroblastom via Stat3/c-Met Pathway.
Title: B7-H3 Regulates Glucose Metabolism in Neuroblastom via Stat3/c-Met Pathway.
Dimerization of the 4Ig isoform of B7-H3 in tumor cells mediates enhanced proliferation and tumorigenic signaling.
Title: Dimerization of the 4Ig isoform of B7-H3 in tumor cells mediates enhanced proliferation and tumorigenic signaling.

Submit: New GeneRIF Correction See all GeneRIFs (210)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-W52184 (e-PCR)
- UniSTS:76570

RH77831 (e-PCR)
- UniSTS:33053

RH44372 (e-PCR)
- UniSTS:615

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune response	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: CD276 antigen

Names: B7 homolog 3; costimulatory molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051242.1 RefSeqGene

Range

5418..35549

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001024736.2 → NP_001019907.1 CD276 antigen isoform a precursor

See identical proteins and their annotated locations for NP_001019907.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK075549, BC062581, CA420873

Consensus CDS

CCDS32288.1

UniProtKB/Swiss-Prot

Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1

UniProtKB/TrEMBL

A8K6Q6

Related

ENSP00000320084.5, ENST00000318443.10

Conserved Domains (2) summary

smart00410
Location:156 → 237

IG_like; Immunoglobulin like

cl11960
Location:261 → 357

Ig; Immunoglobulin domain
NM_001329628.2 → NP_001316557.1 CD276 antigen isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AC022188, AC100838, CA420873

Consensus CDS

CCDS10251.1

UniProtKB/Swiss-Prot

Q5ZPR3
NM_001329629.2 → NP_001316558.1 CD276 antigen isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform a.

Source sequence(s)

AK292711, BC011578, BC062581, CA420873

Consensus CDS

CCDS86475.1

UniProtKB/TrEMBL

A0A0C4DGH0, A8K9J6

Related

ENSP00000441087.2, ENST00000537340.6

Conserved Domains (2) summary

smart00410
Location:10 → 91

IG_like; Immunoglobulin like

cl11960
Location:115 → 211

Ig; Immunoglobulin domain
NM_025240.3 → NP_079516.1 CD276 antigen isoform b precursor

See identical proteins and their annotated locations for NP_079516.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AF302102, AK075549, BC062581, CA420873

Consensus CDS

CCDS10251.1

UniProtKB/Swiss-Prot

Q5ZPR3

Related

ENSP00000320058.5, ENST00000318424.9

Conserved Domains (2) summary

smart00410
Location:156 → 238

IG_like; Immunoglobulin like

cl11960
Location:43 → 139

Ig; Immunoglobulin domain