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    QRFPR pyroglutamylated RFamide peptide receptor [ Homo sapiens (human) ]

    Gene ID: 84109, updated on 2-Nov-2024

    Summary

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    Official Symbol
    QRFPRprovided by HGNC
    Official Full Name
    pyroglutamylated RFamide peptide receptorprovided by HGNC
    Primary source
    HGNC:HGNC:15565
    See related
    Ensembl:ENSG00000186867 MIM:606925; AllianceGenome:HGNC:15565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AQ27; GPR103; SP9155
    Summary
    Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in non-motile cilium. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See QRFPR in Genome Data Viewer
    Location:
    4q27
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (121328642..121381018, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (124632974..124685273, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122249797..122302173, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene neuron derived neurotrophic factor Neighboring gene NDNF antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21864 Neighboring gene TNFAIP3 interacting protein 3 Neighboring gene RNA, U6 small nuclear 948, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:122159169-122159668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:122301959-122302743 Neighboring gene KIAA1191 pseudogene 1 Neighboring gene uncharacterized LOC107986309 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:122332093-122332620 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:122339441-122339942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:122339943-122340442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15658 Neighboring gene TUBB4B pseudogene 5 Neighboring gene uncharacterized LOC107986310

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Two naturally occurring mutations of human GPR103 define distinct G protein selection bias. Ma Q, et al. Biochim Biophys Acta Mol Cell Res, 2021 Jun. PMID 33872671
    2. N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation. Wang W, et al. J Neurochem, 2021 Jul. PMID 33655503
    3. The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling. Li H, et al. J Clin Lab Anal, 2021 Jul. PMID 34018631, Free PMC Article
    4. Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes. Melton PE, et al. J Hypertens, 2019 May. PMID 30633125
    5. Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer. Kawan MA, et al. Oncol Rep, 2019 Feb. PMID 30483810, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling.
      Title: The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling.
    2. N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation.
      Title: N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation.
    3. Two naturally occurring mutations of human GPR103 define distinct G protein selection bias.
      Title: Two naturally occurring mutations of human GPR103 define distinct G protein selection bias.
    4. The expression of both QRFP and GPR103 at the gene and protein level was higher in human prostate cancer tissue samples compared to control and benign prostatic hyperplasia samples.
      Title: Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer.
    5. The study represents the first to use WES in multiplex families for preeclampsia and identifies two novel genes (QRFPR and C1orf35) not previously associated with preeclampsia and find nominal association of rs34270076 with protein levels.
      Title: Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes.
    6. Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.
      Title: Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.
    7. Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.
      Title: GPR103b functions in the peripheral regulation of adipogenesis.
    8. characterization and tissue distribution of SP9155 (GPR103) ligand
      Title: Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.
    9. QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome
      Title: A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC149217

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    pyroglutamylated RF-amide peptide receptor
    Names
    G-protein coupled receptor 103
    QRFP receptor
    orexigenic neuropeptide QRFP receptor
    peptide P518 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198179.3 → NP_937822.2  pyroglutamylated RF-amide peptide receptor

      See identical proteins and their annotated locations for NP_937822.2

      Status: VALIDATED

      Source sequence(s)
      AB109629, AC093867, BG169612, DA461055
      Consensus CDS
      CCDS3719.1
      UniProtKB/Swiss-Prot
      Q96P65
      UniProtKB/TrEMBL
      G4XH69
      Related
      ENSP00000377948.2, ENST00000394427.3
      Conserved Domains (1) summary
      pfam00001
      Location:62 → 332
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      121328642..121381018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008693.3 → XP_016864182.1  pyroglutamylated RF-amide peptide receptor isoform X1

      UniProtKB/TrEMBL
      F2Z3L3
      Related
      ENSP00000423369.1, ENST00000507331.5
      Conserved Domains (2) summary
      cd14964
      Location:48 → 72
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46 → 187
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      124632974..124685273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350983.1 → XP_054206958.1  pyroglutamylated RF-amide peptide receptor isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96P65.2 GenPept UniProtKB/Swiss-Prot:Q96P65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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