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    ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope [ Homo sapiens (human) ]

    Gene ID: 100288413, updated on 28-Oct-2024

    Summary

    Official Symbol
    ERVMER34-1provided by HGNC
    Official Full Name
    endogenous retrovirus group MER34 member 1, envelopeprovided by HGNC
    Primary source
    HGNC:HGNC:42970
    See related
    Ensembl:ENSG00000226887 AllianceGenome:HGNC:42970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEMO; envMER34
    Summary
    Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in placenta (RPKM 6.1), kidney (RPKM 1.4) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ERVMER34-1 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (52742553..52751425, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (56229442..56238314, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (53608720..53617592, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr4:53578367-53579200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21556 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21557 Neighboring gene microRNA 4449 Neighboring gene small nucleolar RNA, H/ACA box 26 Neighboring gene differentiation antagonizing non-protein coding RNA Neighboring gene small nucleolar RNA SNORA26 Neighboring gene uncharacterized LOC107986281 Neighboring gene NANOG hESC enhancer GRCh37_chr4:53632875-53633378 Neighboring gene long intergenic non-protein coding RNA 1618 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:53682350-53682955 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:53682956-53683560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:53698678-53699178 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:53699717-53700574 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:53700575-53701431 Neighboring gene uncharacterized LOC124900700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15428

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12684, FLJ37999, MGC79429, MGC79431, MGC79432

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    endogenous retroviral envelope protein HEMO
    Names
    HERV-MER_4q12 provirus ancestral Env polyprotein
    Human Endogenous MEdium-Reiteration-frequency-family-34 ORF
    LP9056 protein
    endogenous MER34 (medium-reiteration-frequency-family-34) ORF
    endogenous retrovirus group MER34 member 1 Env polyprotein
    endogenous retrovirus group MER34, member 1
    human endogenous MER34 ORF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242690.2NP_001229619.1  endogenous retroviral envelope protein HEMO precursor

      See identical proteins and their annotated locations for NP_001229619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC104066, AY189288, DA633167
      UniProtKB/Swiss-Prot
      B3KTB4, Q0P5R3, Q6NWN0, Q9H9K5
      Related
      ENSP00000460602.1, ENST00000443173.6
      Conserved Domains (1) summary
      cl02885
      Location:401463
      Ebola_HIV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1)
    2. NM_024534.6NP_078810.1  endogenous retroviral envelope protein HEMO precursor

      See identical proteins and their annotated locations for NP_078810.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC104066, AY189288, BC067526, BP871936
      UniProtKB/Swiss-Prot
      B3KTB4, Q0P5R3, Q6NWN0, Q9H9K5
      Related
      ENSP00000460255.1, ENST00000440542.1
      Conserved Domains (1) summary
      cl02885
      Location:401463
      Ebola_HIV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      52742553..52751425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      56229442..56238314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)