smc6 Smc5-6 complex SMC P-loop ATPase subunit Smc6 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: smc6
Official Full Name: Smc5-6 complex SMC P-loop ATPase subunit Smc6
Primary source: PomBase:SPCC5E4.06
Locus tag: SPOM_SPCC5E4.06
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: rad18
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Genomic context

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See smc6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 2

Sequence:: Chromosome: III; NC_003421.2 (652609..656420)

Chromosome III - NC_003421.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo.
Title: Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo.
Authors show that the chromatin association and SUMO ligase activity of Smc5-Smc6 require the Nse5-Nse6 heterodimer, explaining how this nonessential cofactor critically supports the DNA repair roles of Smc5-Smc6.
Title: Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.
I summarize new research that is beginning to tease out the molecular details of Smc5/6 structure and function, knowledge that will illuminate the nuclear activities of Smc5/6 in the stability and dynamics of eukaryotic genomes
Title: The Smc5/6 Complex: New and Old Functions of the Enigmatic Long-Distance Relative.
Study shows that the Smc5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both 'latch' and 'hub' mutations, suggesting a key role for these unique features in controlling DNA association by the Smc5/6 complex.
Title: Specialized interfaces of Smc5/6 control hinge stability and DNA association.
Results provide evidence that Brc1 provides scaffolding functions linking gammaH2A, Rhp18, and Smc5/6 complex at damaged replication forks.
Title: Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.
The function of the SMC5/6 complex and its mammalian homologs in the cell cycle has not been clarified yet.
Title: The (elusive) role of the SMC5/6 complex.
Smc6 is a required for homologous recombination in S. pombe.
Title: Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes.
Smc6 contributes to DNA repair in vivo by targeting the Smc5-6 complex to single-stranded DNA substrates created during the processes of homologous recombination and/or DNA replication.
Title: DNA-binding properties of Smc6, a core component of the Smc5-6 DNA repair complex.
In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that several MAGE proteins can interact with at least one of the NSE4/EID proteins.
Title: Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families.
Data show that defective cohesin removal is a major determinant of the mitotic lethality of Smc5-Smc6 mutants.
Title: Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IC Inferred by Curator more info
enables ATP-dependent activity, acting on DNA	IDA Inferred from Direct Assay more info	PubMed
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to topological DNA co-entrapment activity	NAS Non-traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Smc5-Smc6 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Smc5-Smc6 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Smc5-Smc6 complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Smc5-6 complex SMC P-loop ATPase subunit Smc6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003421.2 Reference assembly

Range

652609..656420

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001022898.3 → NP_587906.1 Smc5-6 complex SMC P-loop ATPase subunit Smc6 [Schizosaccharomyces pombe]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P53692

Conserved Domains (2) summary

cd03276
Location:97 → 252

ABC_SMC6_euk; ATP-binding cassette domain of eukaryotic SM6 proteins

COG1196
Location:16 → 1128

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]