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    TAF4 Taf4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855017, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TAF4
    Official Full Name
    Taf4p
    Primary source
    SGD:S000004607
    Locus tag
    YMR005W
    See related
    AllianceGenome:SGD:S000004607; FungiDB:YMR005W; VEuPathDB:YMR005W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MPT1; TAF48; TSG2
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and chromatin binding activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Orthologous to human TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TAF4 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (276045..277211)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Aim34p Neighboring gene Mvp1p Neighboring gene lysophospholipase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells. Zhang Y, et al. Mol Cell, 2012 Oct 26. PMID 22959270, Free PMC Article
    2. Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domain. Thuault S, et al. J Biol Chem, 2002 Nov 22. PMID 12237303
    3. Intrinsic cooperativity potentiates parallel cis-regulatory evolution. Sorrells TR, et al. Elife, 2018 Sep 10. PMID 30198843, Free PMC Article
    4. Molecular and genetic characterization of a Taf1p domain essential for yeast TFIID assembly. Singh MV, et al. Mol Cell Biol, 2004 Jun. PMID 15143185, Free PMC Article
    5. Kin28 depletion increases association of TFIID subunits Taf1 and Taf4 with promoters in Saccharomyces cerevisiae. Knoll ER, et al. Nucleic Acids Res, 2020 May 7. PMID 32182349, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion or inactivation of Kin28 results in increased occupancy of Taf1 and Taf4 at promoters genome-wide.
      Title: Kin28 depletion increases association of TFIID subunits Taf1 and Taf4 with promoters in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Taf4p
    NP_013718.1
    • TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      276045..277211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182501.1 → NP_013718.1  TPA: Taf4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013718.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZM67, D6VZI0, P50105
      UniProtKB/TrEMBL
      G2WK57
      Conserved Domains (1) summary
      pfam05236
      Location:144 → 383
      TAF4; Transcription initiation factor TFIID component TAF4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50105.1

    Gene LinkOut

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