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    pdc201 pyruvate decarboxylase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543400, updated on 17-Aug-2024

    Summary

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    Gene symbol
    pdc201
    Gene description
    pyruvate decarboxylase
    Primary source
    PomBase:SPAC3G9.11c
    Locus tag
    SPOM_SPAC3G9.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pdc201 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3159811..3162245)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene holo-[acyl-carrier-protein] synthase new8 Neighboring gene exosome 3'-5' phosphorolytic exoribonuclease Rrp41

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast. Kim JY, et al. Aging (Albany NY), 2014 Jul. PMID 25102102, Free PMC Article
    2. A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast. Mathiassen SG, et al. J Biol Chem, 2015 Aug 21. PMID 26152728, Free PMC Article
    3. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
    4. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
    5. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aromatic amino acid family catabolic process to alcohol via Ehrlich pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in generation of precursor metabolites and energy NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in pyruvate metabolic process NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate decarboxylase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3159811..3162245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019502.3 → NP_594083.1  pyruvate decarboxylase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594083.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42873
      Conserved Domains (4) summary
      cd07038
      Location:10 → 173
      TPP_PYR_PDC_IPDC_like; Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins
      COG3961
      Location:3 → 569
      PDC1; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]
      cd02005
      Location:370 → 557
      TPP_PDC_IPDC; Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of ...
      pfam00205
      Location:205 → 320
      TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain
    Nucleotide Protein
    Heading Accession and Version

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