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    BCK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853350, updated on 22-Aug-2024

    Summary

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    Official Symbol
    BCK1
    Primary source
    FungiDB:YJL095W
    Locus tag
    YJL095W
    See related
    SGD:S000003631; AllianceGenome:SGD:S000003631; VEuPathDB:YJL095W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LAS3; SAP3; SLK1; SSP31
    Summary
    Enables MAP kinase kinase kinase activity. Involved in several processes, including cell wall integrity MAPK cascade; endoplasmic reticulum unfolded protein response; and regulation of fungal-type cell wall organization. Located in cellular bud neck; cytoplasm; and mating projection tip. Orthologous to human MAP3K19 (mitogen-activated protein kinase kinase kinase 19). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (247255..251691)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase PHS1 Neighboring gene mitochondrial 54S ribosomal protein YmL49 Neighboring gene Kha1p Neighboring gene Tok1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical requirements for PCBCK1 kinase activity, the Pneumocystis carinii MEKK involved in cell wall integrity. Vohra PK, et al. FEMS Microbiol Lett, 2004 Jun 1. PMID 15158275
    2. Pneumocystis carinii BCK1 complements the Saccharomyces cerevisiae cell wall integrity pathway. Vohra PK, et al. J Eukaryot Microbiol, 2003. PMID 14736215
    3. Pneumocystis carinii BCK1 functions in a mitogen-activated protein kinase cascade regulating fungal cell-wall assembly. Thomas CF Jr, et al. FEBS Lett, 2003 Jul 31. PMID 12885408
    4. A second osmosensing signal transduction pathway in yeast. Hypotonic shock activates the PKC1 protein kinase-regulated cell integrity pathway. Davenport KR, et al. J Biol Chem, 1995 Dec 15. PMID 8530423
    5. A new protein kinase, SSP31, modulating the SMP3 gene-product involved in plasmid maintenance in Saccharomyces cerevisiae. Irie K, et al. Gene, 1991 Dec 1. PMID 1840547

    See all (221) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data discovered that six non-essential protein kinase (PKase) disruptions (Deltabck1, Deltamkk1, Deltaslt2/Deltampk1, Deltamck1, Deltassk2 and Deltayak1) suppressed the Cas-phenotype of the Deltaptp2 Deltamsg5 double disruptant.
      Title: Identification of protein kinase disruptions as suppressors of the calcium sensitivity of S. cerevisiae Deltaptp2 Deltamsg5 protein phosphatase double disruptant.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall integrity MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase BCK1
    NP_012440.1
    • MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      247255..251691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181528.1 → NP_012440.1  TPA: mitogen-activated protein kinase kinase kinase BCK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW89, P32894, Q01389
      UniProtKB/TrEMBL
      B3LQ18, D3UF59
      Conserved Domains (1) summary
      cd06629
      Location:1173 → 1440
      STKc_Bck1_like; Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01389.1

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