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    tif222 translation initiation factor eIF2B beta subunit [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543035, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tif222
    Official Full Name
    translation initiation factor eIF2B beta subunit
    Primary source
    PomBase:SPAC343.14c
    Locus tag
    SPOM_SPAC343.14C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tif222 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (1672197..1673676, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene glutamyl-tRNA amidotransferase beta subunit Gta2 Neighboring gene ncRNA Neighboring gene WD repeat-containing protein Neighboring gene tRNA isopentenyltransferase Neighboring gene homoaconitate hydratase Lys2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. Kashiwagi K, et al. J Struct Funct Genomics, 2016 Mar. PMID 27023709, Free PMC Article
    2. Structural basis for eIF2B inhibition in integrated stress response. Kashiwagi K, et al. Science, 2019 May 3. PMID 31048492
    3. Crystal structure of eukaryotic translation initiation factor 2B. Kashiwagi K, et al. Nature, 2016 Mar 3. PMID 26901872
    4. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF2B beta subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1672197..1673676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018868.3 → NP_593435.1  translation initiation factor eIF2B beta subunit [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593435.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UT76
      Conserved Domains (2) summary
      COG1184
      Location:8 → 387
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:24 → 375
      IF-2B; Initiation factor 2 subunit family
    Nucleotide Protein
    Heading Accession and Version

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