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    TIF4631 translation initiation factor eIF4G [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853071, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TIF4631
    Official Full Name
    translation initiation factor eIF4G
    Primary source
    SGD:S000003394
    Locus tag
    YGR162W
    See related
    AllianceGenome:SGD:S000003394; FungiDB:YGR162W; VEuPathDB:YGR162W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase activator activity and RNA binding activity. Involved in several processes, including cellular response to glucose starvation; positive regulation of formation of translation preinitiation complex; and stress granule assembly. Located in P-body and cytoplasmic stress granule. Part of eukaryotic translation initiation factor 4F complex. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to several human genes including EIF4G2 (eukaryotic translation initiation factor 4 gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TIF4631 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (824059..826917)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-Val Neighboring gene Gtr2p Neighboring gene tRNA-Arg Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Cap-binding protein eIF4E promotes folding of a functional domain of yeast translation initiation factor eIF4G1. Hershey PE, et al. J Biol Chem, 1999 Jul 23. PMID 10409688
    2. Translational control of gene expression noise and its relationship to ageing in yeast. Carolina de Souza-Guerreiro T, et al. FEBS J, 2021 Apr. PMID 33090724
    3. Translation initiation factor eIF4G1 preferentially binds yeast transcript leaders containing conserved oligo-uridine motifs. Zinshteyn B, et al. RNA, 2017 Sep. PMID 28546148, Free PMC Article
    4. The RNA Helicase Ded1 Regulates Translation and Granule Formation during Multiple Phases of Cellular Stress Responses. Aryanpur PP, et al. Mol Cell Biol, 2022 Jan 20. PMID 34723653, Free PMC Article
    5. RGG-motif containing mRNA export factor Gbp2 acts as a translation repressor. Poornima G, et al. RNA Biol, 2021 Dec. PMID 33910495, Free PMC Article

    See all (181) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that putative serine/threonine protein kinase KSP1 (Ksp1) directly phosphorylates eukaryotic translation initiation factor 4G (eIF4G).
      Title: Ksp1-dependent phosphorylation of eIF4G modulates post-transcriptional regulation of specific mRNAs under glucose deprivation conditions.
    2. Pub1p C-terminal RRM domain interacts with Tif4631p through a conserved region neighbouring the Pab1p binding site
      Title: Pub1p C-terminal RRM domain interacts with Tif4631p through a conserved region neighbouring the Pab1p binding site.
    3. The RNA-binding region (RNA1) in the N-terminal domain (NTD) of yeast eIF4G1 can functionally substitute for the PABP-binding segment to rescue the function of an eIF4G1-459 mutant impaired for eIF4E binding.
      Title: Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo.
    4. Data show that that deletion of eIF4G1, but not eIF4G2, impairs growth and global translation initiation rates.
      Title: Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae.
    5. involvement of yeast eIF4G in pre-mRNA metabolism; Tif4631p and Tif4632p interact efficiently with U1 snRNA; Tif4631p and Tif4632p associate with protein components of the splicing machinery, namely Snu71p and Prp11p.
      Title: Interaction of yeast eIF4G with spliceosome components: implications in pre-mRNA processing events.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of formation of translation preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF4G
    NP_011678.3
    • Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); stimulates the ATPase and helicase activities of eIF4A synergistically with eIF4G; required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; association with Pab1p mediates poly(A) tail-stimulated translation; role in assembly of PET region in biogenesis of 60S ribosomal subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      824059..826917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181291.3 → NP_011678.3  TPA: translation initiation factor eIF4G [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011678.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUU6, P39935
      UniProtKB/TrEMBL
      B3LI68, C7GQ70, C8Z957, N1P2E4
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 362
      PTZ00121; MAEBL; Provisional
      TIGR01622
      Location:489 → 562
      SF-CC1; splicing factor, CC1-like family
      pfam02854
      Location:607 → 850
      MIF4G; MIF4G domain
      pfam12152
      Location:411 → 469
      eIF_4G1; Eukaryotic translation initiation factor 4G1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39935.2

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