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    ITC1 Itc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852744, updated on 26-Jun-2024

    Summary

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    Gene symbol
    ITC1
    Gene description
    Itc1p
    Primary source
    FungiDB:YGL133W
    Locus tag
    YGL133W
    See related
    SGD:S000003101; AllianceGenome:SGD:S000003101; VEuPathDB:YGL133W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in negative regulation of transcription from RNA polymerase II promoter by pheromones and subtelomeric heterochromatin assembly. Located in nucleus. Part of CHRAC. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ITC1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (257707..261501)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L1B Neighboring gene Pcl10p Neighboring gene DNA-binding E3 ubiquitin-protein ligase SNT2 Neighboring gene mRNA guanylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA. Hwang WL, et al. Nature, 2014 Aug 14. PMID 25043036, Free PMC Article
    2. The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes. Brestovitsky A, et al. Nucleic Acids Res, 2011 Aug. PMID 21546548, Free PMC Article
    3. Kinetic mechanism for single-stranded DNA binding and translocation by Saccharomyces cerevisiae Isw2. Fischer CJ, et al. Biochemistry, 2009 Apr 7. PMID 19203228, Free PMC Article
    4. Baculovirus expression system for heterologous multiprotein complexes. Berger I, et al. Nat Biotechnol, 2004 Dec. PMID 15568020
    5. Cell-type-dependent repression of yeast a-specific genes requires Itc1p, a subunit of the Isw2p-Itc1p chromatin remodelling complex. Ruiz C, et al. Microbiology (Reading), 2003 Feb. PMID 12624196

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Basis of specificity for a conserved and promiscuous chromatin remodeling protein.
      Title: Basis of specificity for a conserved and promiscuous chromatin remodeling protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CHRAC IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Itc1p
    NP_011382.1
    • Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      257707..261501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180998.1 → NP_011382.1  TPA: Itc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011382.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU16, P53125
      UniProtKB/TrEMBL
      A0A8H4FA37, B3LHJ1, C7GX66, C8Z8B7, N1P1P5
      Conserved Domains (3) summary
      smart00571
      Location:423 → 483
      DDT; domain in different transcription and chromosome remodeling factors
      pfam10537
      Location:24 → 124
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15613
      Location:869 → 952
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53125.1

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