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    NSL1 MIND complex subunit NSL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855843, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NSL1
    Official Full Name
    MIND complex subunit NSL1
    Primary source
    SGD:S000006154
    Locus tag
    YPL233W
    See related
    AllianceGenome:SGD:S000006154; FungiDB:YPL233W; VEuPathDB:YPL233W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in chromosome segregation. Located in kinetochore and spindle pole. Part of nuclear MIS12/MIND complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NSL1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (106172..106822)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene RuvB family ATP-dependent DNA helicase reptin Neighboring gene H(+)-transporting V0 sector ATPase subunit c' Neighboring gene syntaxin Neighboring gene trifunctional fatty acid synthase subunit FAS2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C-Terminal Motifs of the MTW1 Complex Cooperatively Stabilize Outer Kinetochore Assembly in Budding Yeast. Ghodgaonkar-Steger M, et al. Cell Rep, 2020 Sep 29. PMID 32997987
    2. Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Dimitrova YN, et al. Cell, 2016 Nov 3. PMID 27881300, Free PMC Article
    3. Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. Scharfenberger M, et al. EMBO J, 2003 Dec 15. PMID 14657030, Free PMC Article
    4. Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Euskirchen GM. Eukaryot Cell, 2002 Apr. PMID 12455957, Free PMC Article
    5. An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Pinsky BA, et al. Dev Cell, 2003 Nov. PMID 14602074

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MIS12/MIND type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MIND complex subunit NSL1
    NP_015091.1
    • Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      106172..106822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184047.1 → NP_015091.1  TPA: MIND complex subunit NSL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015091.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3D7, Q12143, Q6B152
      UniProtKB/TrEMBL
      A6ZW22, B3LKJ8, C7GU72, C8ZIE6, G2WNV2, N1NVM3
      Conserved Domains (1) summary
      pfam08641
      Location:62 → 194
      Mis14; Kinetochore protein Mis14 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12143.1

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