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    BDH2 putative dehydrogenase BDH2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851238, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BDH2
    Official Full Name
    putative dehydrogenase BDH2
    Primary source
    SGD:S000000057
    Locus tag
    YAL061W
    See related
    AllianceGenome:SGD:S000000057; FungiDB:YAL061W; VEuPathDB:YAL061W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable (R,R)-butanediol dehydrogenase activity. Predicted to be involved in butanediol biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human ZADH2 (zinc binding alcohol dehydrogenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BDH2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (33448..34701)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene flocculin FLO9 Neighboring gene glutamate dehydrogenase (NADP(+)) GDH3 Neighboring gene (R,R)-butanediol dehydrogenase Neighboring gene Ecm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into two yeast BDHs from the PDH subfamily as aldehyde reductases in context of detoxification of lignocellulosic aldehyde inhibitors. Kuang X, et al. Appl Microbiol Biotechnol, 2020 Aug. PMID 32556414
    2. The yeast ADH7 promoter enables gene expression under pronounced translation repression caused by the combined stress of vanillin, furfural, and 5-hydroxymethylfurfural. Ishida Y, et al. J Biotechnol, 2017 Jun 20. PMID 28458045
    3. Prioritized Expression of BDH2 under Bulk Translational Repression and Its Contribution to Tolerance to Severe Vanillin Stress in Saccharomyces cerevisiae. Ishida Y, et al. Front Microbiol, 2016. PMID 27458450, Free PMC Article
    4. Increasing Yield of 2,3,5,6-Tetramethylpyrazine in Baijiu Through Saccharomyces cerevisiae Metabolic Engineering. Cui DY, et al. Front Microbiol, 2020. PMID 33324376, Free PMC Article
    5. The VFH1 (YLL056C) promoter is vanillin-inducible and enables mRNA translation despite pronounced translation repression caused by severe vanillin stress in Saccharomyces cerevisiae. Nguyen TTM, et al. Yeast, 2018 Jul. PMID 29575020

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables (R,R)-butanediol dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacetyl reductase ((R)-acetoin forming) (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in butanediol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative dehydrogenase BDH2
    NP_009340.1
    • Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      33448..34701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178203.1 → NP_009340.1  TPA: putative dehydrogenase BDH2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009340.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPF8, P39713
      UniProtKB/TrEMBL
      A0A7S8WHP8, A7A0A8, C8Z3M8, G2W8H2
      Conserved Domains (1) summary
      cd08233
      Location:1 → 375
      butanediol_DH_like; (2R,3R)-2,3-butanediol dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39713.1

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