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    adf1 cofilin [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541738, updated on 18-Sep-2024

    Summary

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    Official Symbol
    adf1
    Official Full Name
    cofilin
    Primary source
    PomBase:SPAC20G4.06c
    Locus tag
    SPOM_SPAC20G4.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cof1
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    Genomic context

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    See adf1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4825257..4826126, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene adenylyltransferase Neighboring gene ncRNA Neighboring gene C-24(28) sterol reductase Erg4 Neighboring gene ncRNA Neighboring gene protein pdc1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. Andrianantoandro E, et al. Mol Cell, 2006 Oct 6. PMID 17018289
    2. Fission yeast Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis. Ueda EI, et al. Biochem Biophys Res Commun, 2018 Nov 25. PMID 30201262
    3. Purification of actin from fission yeast Schizosaccharomyces pombe and characterization of functional differences from muscle actin. Ti SC, et al. J Biol Chem, 2011 Feb 18. PMID 21148484, Free PMC Article
    4. Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring. Takaine M, et al. EMBO J, 2009 Oct 21. PMID 19713940, Free PMC Article
    5. Actin filament severing by cofilin dismantles actin patches and produces mother filaments for new patches. Chen Q, et al. Curr Biol, 2013 Jul 8. PMID 23727096, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis.
      Title: Fission yeast Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis.
    2. These measurements support a cofilin-severing mechanism in which mechanical asymmetry promotes local stress accumulation and fragmentation at boundaries of bare and cofilin-decorated segments, analogous to failure of some nonprotein materials.
      Title: Cofilin-linked changes in actin filament flexibility promote severing.
    3. Furthermore, Cdc8, Fim1, and Adf1 all compete for association with F-actin by different mechanisms, and their cooperative association with actin filaments affects their ability to compete.
      Title: Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.
    4. Cofilin rapidly dissociates Arp2/3 complex and branches by direct competition for binding sites on the actin filament and by propagation of structural changes in the actin filament that reduce affinity for Arp2/3 complex.
      Title: Cofilin dissociates Arp2/3 complex and branches from actin filaments.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament debranching activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament severing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin monomer binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell division site HDA PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cofilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4825257..4826126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020169.3 → NP_594741.1  cofilin [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594741.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78929
      Conserved Domains (1) summary
      cd11286
      Location:4 → 134
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
    Nucleotide Protein
    Heading Accession and Version

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