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    MOB2 MOB kinase activator 2 [ Homo sapiens (human) ]

    Gene ID: 81532, updated on 6-Jun-2024

    Summary

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    Official Symbol
    MOB2provided by HGNC
    Official Full Name
    MOB kinase activator 2provided by HGNC
    Primary source
    HGNC:HGNC:24904
    See related
    Ensembl:ENSG00000182208 MIM:611969; AllianceGenome:HGNC:24904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCCA2
    Summary
    Predicted to enable metal ion binding activity. Predicted to act upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Ubiquitous expression in skin (RPKM 12.1), endometrium (RPKM 11.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MOB2 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1469448..1486779, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1543884..1615049, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1490678..1508009, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1374637-1375384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1380465-1380966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1380967-1381466 Neighboring gene long intergenic non-protein coding RNA 2689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3054 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1405373-1405546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3055 Neighboring gene MPRA-validated peak1160 silencer Neighboring gene BR serine/threonine kinase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1458078-1458816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1469339-1469838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1474249-1474958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1479210-1479772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1520757-1521279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1528327-1529160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1529995-1530826 Neighboring gene uncharacterized LOC124902607 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534293-1534794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534795-1535294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541250-1541750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541751-1542251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4289 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1547587-1548086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1553250-1553750 Neighboring gene uncharacterized LOC124902608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1576597-1577394 Neighboring gene dual specificity phosphatase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling. Jiang K, et al. Cell Death Dis, 2020 Apr 14. PMID 32286266, Free PMC Article
    2. Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2. Wu W, et al. Oncol Rep, 2015 May. PMID 25779224
    3. Regulation of DNA damage responses and cell cycle progression by hMOB2. Gomez V, et al. Cell Signal, 2015 Feb. PMID 25460043, Free PMC Article
    4. Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721. Leng JJ, et al. World J Gastroenterol, 2012 Dec 28. PMID 23326134, Free PMC Article
    5. Gene expression profile in Alzheimer's brain screened by molecular indexing. Doyu M, et al. Brain Res Mol Brain Res, 2001 Feb 19. PMID 11223154

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling.
      Title: MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling.
    2. The altered cell-matrix adhesion and cell motility induced by hMOB2 expression was caused by the assembly of focal adhesions.
      Title: Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2.
    3. hMOB2 interacts with RAD50, facilitating the recruitment of the MRE11-RAD50-NBS1 (MRN) DNA damage sensor complex and activated ATM to DNA damaged chromatin.
      Title: Regulation of DNA damage responses and cell cycle progression by hMOB2.
    4. MOB2 overexpression induces apoptosis and inhibits the growth of human hepatic cancer cells
      Title: Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721.
    5. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
      Title: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
    6. Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings.
      Title: Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Binds to and stimulates the kinase activity of the related human serine-threonine kinases NDR1 and NDR2.
      Title: Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MOB kinase activator 2
    Names
    MOB2 Mps One Binder homolog
    Mps one binder kinase activator-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172223.3 → NP_001165694.1  MOB kinase activator 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC091196, AK296658, AW874617, BC047291, DC413532
      Consensus CDS
      CCDS53591.1
      UniProtKB/Swiss-Prot
      Q70IA6
      Related
      ENSP00000328694.6, ENST00000329957.7
      Conserved Domains (1) summary
      pfam03637
      Location:63 → 231
      Mob1_phocein; Mob1/phocein family

    2. NM_053005.5 → NP_443731.2  MOB kinase activator 2 isoform 2

      See identical proteins and their annotated locations for NP_443731.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AW874617, BC047291, BC067785, BP388313, DC413532, HY032250
      UniProtKB/Swiss-Prot
      B4DKP3, Q70IA6, Q96M67
      Conserved Domains (1) summary
      pfam03637
      Location:32 → 200
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      1469448..1486779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791792.1 Reference GRCh38.p14 PATCHES

      Range
      203714..274494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333117.1 → XP_054189092.1  MOB kinase activator 2 isoform X3

    2. XM_054333119.1 → XP_054189094.1  MOB kinase activator 2 isoform X5

      UniProtKB/TrEMBL
      B4DTJ1

    3. XM_054333116.1 → XP_054189091.1  MOB kinase activator 2 isoform X2

    4. XM_054333115.1 → XP_054189090.1  MOB kinase activator 2 isoform X1

    5. XM_054333120.1 → XP_054189095.1  MOB kinase activator 2 isoform X6

    6. XM_054333121.1 → XP_054189096.1  MOB kinase activator 2 isoform X7

    7. XM_054333118.1 → XP_054189093.1  MOB kinase activator 2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      1543884..1615049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370056.1 → XP_054226031.1  MOB kinase activator 2 isoform X9

    2. XM_054370058.1 → XP_054226033.1  MOB kinase activator 2 isoform X11

      UniProtKB/TrEMBL
      B4DTJ1

    3. XM_054370055.1 → XP_054226030.1  MOB kinase activator 2 isoform X8

    4. XM_054370059.1 → XP_054226034.1  MOB kinase activator 2 isoform X12

    5. XM_054370060.1 → XP_054226035.1  MOB kinase activator 2 isoform X13

    6. XM_054370057.1 → XP_054226032.1  MOB kinase activator 2 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q70IA6.1 GenPept UniProtKB/Swiss-Prot:Q70IA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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