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    ANT1 Ant1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856246, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ANT1
    Official Full Name
    Ant1p
    Primary source
    SGD:S000006332
    Locus tag
    YPR128C
    See related
    AllianceGenome:SGD:S000006332; FungiDB:YPR128C; VEuPathDB:YPR128C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables adenine nucleotide transmembrane transporter activity. Involved in ATP transport; fatty acid beta-oxidation; and peroxisome organization. Located in peroxisomal membrane. Orthologous to human SLC25A17 (solute carrier family 25 member 17). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ANT1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (791218..792204, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ylh47p Neighboring gene pyridoxine 4-dehydrogenase Neighboring gene Scd6p Neighboring gene peptide alpha-N-acetyltransferase complex B subunit NAT3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter. Palmieri L, et al. EMBO J, 2001 Sep 17. PMID 11566870, Free PMC Article
    2. Identification of a peroxisomal ATP carrier required for medium-chain fatty acid beta-oxidation and normal peroxisome proliferation in Saccharomyces cerevisiae. van Roermund CW, et al. Mol Cell Biol, 2001 Jul. PMID 11390660, Free PMC Article
    3. Incorporation of adenine nucleotide transporter, Ant1p, into proteoliposomes facilitates ATP translocation and activation of encapsulated luciferase. Nozawa A, et al. J Biosci Bioeng, 2014 Aug. PMID 24656877
    4. The yeast peroxisomal adenine nucleotide transporter: characterization of two transport modes and involvement in DeltapH formation across peroxisomal membranes. Lasorsa FM, et al. Biochem J, 2004 Aug 1. PMID 15219179, Free PMC Article
    5. The peroxisomal transporter gene ANT1 is regulated by a deviant oleate response element (ORE): characterization of the signal for fatty acid induction. Rottensteiner H, et al. Biochem J, 2002 Jul 1. PMID 12071844, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria.
      Title: Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ADP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenine nucleotide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenine nucleotide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ADP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ant1p
    NP_015453.1
    • Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      791218..792204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184225.1 → NP_015453.1  TPA: Ant1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4C5, Q06497
      UniProtKB/TrEMBL
      A6ZX07, B3LK90, B5VTR6, C8ZJF0, N1NW51
      Conserved Domains (1) summary
      pfam00153
      Location:3 → 106
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06497.1

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