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    MSN1 Msn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854033, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MSN1
    Official Full Name
    Msn1p
    Primary source
    SGD:S000005476
    Locus tag
    YOL116W
    See related
    AllianceGenome:SGD:S000005476; FungiDB:YOL116W; VEuPathDB:YOL116W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUP1; HRB382; MSS10; PHD2
    Summary
    Enables sequence-specific DNA binding activity. Involved in several processes, including cellular hyperosmotic salinity response; positive regulation of growth of unicellular organism as a thread of attached cells; and positive regulation of macromolecule metabolic process. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MSN1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (99809..100957)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rri2p Neighboring gene non-canonical poly(A) polymerase PAP2 Neighboring gene Pth4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae. Eide D, et al. J Gen Microbiol, 1992 Feb. PMID 1564445
    2. Expression of yeast transcriptional activator MSN1 promotes accumulation of chromium and sulfur by enhancing sulfate transporter level in plants. Kim YJ, et al. FEBS Lett, 2006 Jan 9. PMID 16364322
    3. A multicopy suppressor gene, MSS10, restores STA2 expression in Saccharomyces cerevisiae strains containing the STA10 repressor gene. Lambrechts MG, et al. Curr Genet, 1996 May. PMID 8662191
    4. The putative transcriptional activator MSN1 promotes chromium accumulation in Saccharomyces cerevisiae. Chang KS, et al. Mol Cells, 2003 Dec 31. PMID 14744017
    5. Increased dosage of the MSN1 gene restores invertase expression in yeast mutants defective in the SNF1 protein kinase. Estruch F, et al. Nucleic Acids Res, 1990 Dec 11. PMID 2263457, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic salinity response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to methylglyoxal IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of starch catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Msn1p
    NP_014525.1
    • Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      99809..100957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183370.1 → NP_014525.1  TPA: Msn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1V1, P22148, Q12227, Q9URF6
      UniProtKB/TrEMBL
      B3LIU9, C7GSS0, G2WMC0, N1NXH5
      Conserved Domains (1) summary
      pfam12550
      Location:278 → 356
      GCR1_C; Transcriptional activator of glycolytic enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22148.2

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