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    CASC2 cancer susceptibility 2 [ Homo sapiens (human) ]

    Gene ID: 255082, updated on 28-Oct-2024

    Summary

    Official Symbol
    CASC2provided by HGNC
    Official Full Name
    cancer susceptibility 2provided by HGNC
    Primary source
    HGNC:HGNC:22933
    See related
    Ensembl:ENSG00000177640 MIM:608598; AllianceGenome:HGNC:22933
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf5
    Summary
    Involved in defense response to tumor cell; negative regulation of MAPK cascade; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in thyroid (RPKM 1.0), brain (RPKM 1.0) and 22 other tissues See more
    NEW
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    Genomic context

    See CASC2 in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (118046821..118210153)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (118940870..119104994)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (119806332..119969665)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2674 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119545298-119545468 Neighboring gene VISTA enhancer hs1236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:119597764-119598550 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:119658461-119659162 Neighboring gene uncharacterized LOC105378504 Neighboring gene VISTA enhancer hs1551 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:119739304-119740503 Neighboring gene RAB11 family interacting protein 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119795138-119795331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2863 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119907111-119907355 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:119963650-119964234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:119964235-119964819 Neighboring gene Sharpr-MPRA regulatory region 3281 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:119973305-119974504 Neighboring gene long intergenic non-protein coding RNA 2944 Neighboring gene NANOG hESC enhancer GRCh37_chr10:120025545-120026208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120044911-120045412 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120045413-120045912 Neighboring gene VISTA enhancer hs672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120101641-120102140 Neighboring gene family with sequence similarity 204 member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • cancer susceptibility 2 (non-protein coding)
    • cancer susceptibility candidate 2 (non-protein coding)

    Clone Names

    • MGC117219

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026939.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC005879, AC022395, AI219353, BC036393, BC112306
      Related
      ENST00000435944.5
    2. NR_026940.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' region, compared to variant 1.
      Source sequence(s)
      AC005879, AC022395, AI219353, AJ535621, BC036393
      Related
      ENST00000665675.1
    3. NR_026941.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 3' splice pattern, compared to variant 1.
      Source sequence(s)
      AC022395, AJ344228, BC036393, BC112326

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      118046821..118210153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      118940870..119104994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178816.2: Suppressed sequence

      Description
      NM_178816.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    2. NM_201377.1: Suppressed sequence

      Description
      NM_201377.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.