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    MCHR1 melanin concentrating hormone receptor 1 [ Homo sapiens (human) ]

    Gene ID: 2847, updated on 28-Oct-2024

    Summary

    Official Symbol
    MCHR1provided by HGNC
    Official Full Name
    melanin concentrating hormone receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:4479
    See related
    Ensembl:ENSG00000128285 MIM:601751; AllianceGenome:HGNC:4479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLC1; GPR24; MCH1R; SLC-1; MCH-1R
    Summary
    The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 4.7), ovary (RPKM 1.2) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MCHR1 in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (40679484..40682812)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (41151449..41154777)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41075488..41078816)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905122 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:41047623-41048822 Neighboring gene CRISPRi-validated cis-regulatory element chr22.2152 Neighboring gene uncharacterized LOC124905123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41060823-41061338 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41072002-41072502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41075515-41076208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41076631-41077585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41077586-41078539 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 37 Neighboring gene Sharpr-MPRA regulatory regions 5578 and 9058 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41079701-41080396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41080397-41081092 Neighboring gene Sharpr-MPRA regulatory region 1401 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41107927-41108443 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41109407-41110282 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41110283-41111157 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:41111979-41112145 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41117878-41118491 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41124025-41124749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41124750-41125473 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:41127319-41127477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13774 Neighboring gene solute carrier family 25 member 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41178069-41178568 Neighboring gene RFK pseudogene 4 Neighboring gene jumping translocation breakpoint pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC32129

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables melanin-concentrating hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in non-motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    melanin-concentrating hormone receptor 1
    Names
    G protein-coupled receptor 24
    MCH receptor 1
    somatostatin receptor-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029686.1 RefSeqGene

      Range
      5307..8635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005297.4NP_005288.4  melanin-concentrating hormone receptor 1

      Status: REVIEWED

      Source sequence(s)
      Z86090
      Consensus CDS
      CCDS14004.2
      UniProtKB/Swiss-Prot
      B2RBX6, Q5R3J1, Q96S47, Q99705, Q9BV08
      UniProtKB/TrEMBL
      Q5IFI4
      Related
      ENSP00000249016.5, ENST00000249016.5
      Conserved Domains (1) summary
      cd15338
      Location:41322
      7tmA_MCHR1; melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      40679484..40682812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      41151449..41154777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)