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    ZC3H12B zinc finger CCCH-type containing 12B [ Homo sapiens (human) ]

    Gene ID: 340554, updated on 28-Oct-2024

    Summary

    Official Symbol
    ZC3H12Bprovided by HGNC
    Official Full Name
    zinc finger CCCH-type containing 12Bprovided by HGNC
    Primary source
    HGNC:HGNC:17407
    See related
    Ensembl:ENSG00000102053 MIM:300889; AllianceGenome:HGNC:17407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCPIP2; CXorf32
    Summary
    The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in brain (RPKM 1.1), ovary (RPKM 0.5) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZC3H12B in Genome Data Viewer
    Location:
    Xq11.2-q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (65034826..65507887)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (63460180..63934332)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64254706..64727767)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373239 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:64195850-64196393 Neighboring gene zinc finger C4H2-type containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29712 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:64394379-64394544 Neighboring gene karyopherin subunit alpha 2 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:64416296-64416796 Neighboring gene Sharpr-MPRA regulatory region 9838 Neighboring gene NANOG hESC enhancer GRCh37_chrX:64519957-64520668 Neighboring gene chaperonin containing TCP1 subunit 4 pseudogene 2 Neighboring gene mortality factor 4 like 1 pseudogene 5 Neighboring gene NANOG hESC enhancer GRCh37_chrX:64612699-64613200 Neighboring gene PRXL2C pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chrX:64658617-64659137 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:64683306-64683834 Neighboring gene TLE family member 1 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:64713210-64713789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:64722192-64722692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:64722693-64723193 Neighboring gene AP1M2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29713 Neighboring gene LAS1 like ribosome biogenesis factor Neighboring gene FERM domain containing 8 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    probable ribonuclease ZC3H12B
    Names
    MCP-induced protein 2
    zinc finger CCCH domain-containing protein 12B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021264.2 RefSeqGene

      Range
      5001..24153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001010888.4NP_001010888.3  probable ribonuclease ZC3H12B

      See identical proteins and their annotated locations for NP_001010888.3

      Status: VALIDATED

      Source sequence(s)
      AL050306, AL355606, AL441964, AL591202, Z83841
      Consensus CDS
      CCDS48131.2
      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Related
      ENSP00000340839.4, ENST00000338957.5
      Conserved Domains (1) summary
      pfam11977
      Location:189345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      65034826..65507887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442075.1XP_047298031.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    2. XM_047442077.1XP_047298033.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    3. XM_047442076.1XP_047298032.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    4. XM_047442074.1XP_047298030.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    5. XM_047442079.1XP_047298035.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    6. XM_017029484.2XP_016884973.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
    7. XM_047442078.1XP_047298034.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    8. XM_047442080.1XP_047298036.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    9. XM_017029479.2XP_016884968.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
    10. XM_017029480.2XP_016884969.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
    11. XM_017029481.2XP_016884970.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
    12. XM_017029482.2XP_016884971.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
    13. XM_017029483.2XP_016884972.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
    14. XM_011530939.3XP_011529241.1  probable ribonuclease ZC3H12B isoform X1

      See identical proteins and their annotated locations for XP_011529241.1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Related
      ENSP00000512584.1, ENST00000696370.1
      Conserved Domains (1) summary
      pfam11977
      Location:189345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      63460180..63934332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326986.1XP_054182961.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    2. XM_054326980.1XP_054182955.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    3. XM_054326981.1XP_054182956.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    4. XM_054326975.1XP_054182950.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    5. XM_054326985.1XP_054182960.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    6. XM_054326983.1XP_054182958.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    7. XM_054326984.1XP_054182959.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    8. XM_054326987.1XP_054182962.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    9. XM_054326976.1XP_054182951.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    10. XM_054326977.1XP_054182952.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    11. XM_054326978.1XP_054182953.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    12. XM_054326979.1XP_054182954.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    13. XM_054326982.1XP_054182957.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
    14. XM_054326988.1XP_054182963.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0