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    TNKS2 tankyrase 2 [ Homo sapiens (human) ]

    Gene ID: 80351, updated on 3-Nov-2024

    Summary

    Official Symbol
    TNKS2provided by HGNC
    Official Full Name
    tankyrase 2provided by HGNC
    Primary source
    HGNC:HGNC:15677
    See related
    Ensembl:ENSG00000107854 MIM:607128; AllianceGenome:HGNC:15677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c
    Summary
    Enables NAD+-protein poly-ADP-ribosyltransferase activity and enzyme binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TNKS2 in Genome Data Viewer
    Location:
    10q23.32
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (91798426..91865475)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (92681611..92748788)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93558183..93625232)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902482 Neighboring gene TNKS2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2609 Neighboring gene NANOG hESC enhancer GRCh37_chr10:93580083-93580584 Neighboring gene signal recognition particle 9 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:93640869-93641370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:93641371-93641870 Neighboring gene Sharpr-MPRA regulatory region 9903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:93682269-93682802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3766 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+-protein ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, telomeric region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    poly [ADP-ribose] polymerase tankyrase-2
    Names
    ADP-ribosyltransferase diphtheria toxin-like 6
    TNKS-2
    TRF1-interacting ankyrin-related ADP-ribose polymerase 2
    poly [ADP-ribose] polymerase 5B
    protein poly-ADP-ribosyltransferase tankyrase-2
    tankyrase II
    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
    tankyrase-like protein
    tankyrase-related protein
    NP_079511.1
    XP_011538515.1
    XP_016872188.1
    XP_016872189.2
    XP_016872190.1
    XP_047281751.1
    XP_054222802.1
    XP_054222803.1
    XP_054222804.1
    XP_054222805.1
    XP_054222806.1
    XP_054222807.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025235.4NP_079511.1  poly [ADP-ribose] polymerase tankyrase-2

      See identical proteins and their annotated locations for NP_079511.1

      Status: VALIDATED

      Source sequence(s)
      AF309033, AF438201, BQ019749
      Consensus CDS
      CCDS7417.1
      UniProtKB/Swiss-Prot
      B2RBD3, Q9H2K2, Q9H8F2, Q9HAS4
      UniProtKB/TrEMBL
      A0AA34QVI1
      Related
      ENSP00000360689.4, ENST00000371627.5
      Conserved Domains (6) summary
      PHA02876
      Location:73458
      PHA02876; ankyrin repeat protein; Provisional
      cd09524
      Location:871936
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      PHA03095
      Location:494802
      PHA03095; ankyrin-like protein; Provisional
      cd01438
      Location:9381160
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      sd00045
      Location:528556
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:4396
      Ank_5; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      91798426..91865475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540213.2XP_011538515.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

      UniProtKB/TrEMBL
      A0AA34QVI1
      Conserved Domains (6) summary
      PHA02876
      Location:94479
      PHA02876; ankyrin repeat protein; Provisional
      cd09524
      Location:892957
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      PHA03095
      Location:515823
      PHA03095; ankyrin-like protein; Provisional
      cd01438
      Location:9591181
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      sd00045
      Location:549577
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:28142
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_017016701.2XP_016872190.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X4

      Conserved Domains (3) summary
      PHA02876
      Location:94479
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:234262
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:28142
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_047425795.1XP_047281751.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X5

    4. XM_017016699.2XP_016872188.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

      UniProtKB/TrEMBL
      A0AA34QVI1
      Conserved Domains (5) summary
      cd09524
      Location:764829
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      PHA03095
      Location:387695
      PHA03095; ankyrin-like protein; Provisional
      cd01438
      Location:8311053
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      sd00045
      Location:421449
      ANK; ANK repeat [structural motif]
      cl39094
      Location:100365
      Ank_2; Ankyrin repeats (3 copies)
    5. XM_017016700.3XP_016872189.2  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      92681611..92748788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366827.1XP_054222802.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

    2. XM_054366830.1XP_054222805.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X4

    3. XM_054366831.1XP_054222806.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X5

    4. XM_054366828.1XP_054222803.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

    5. XM_054366832.1XP_054222807.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X6

    6. XM_054366829.1XP_054222804.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X3