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    PAIP2 poly(A) binding protein interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 51247, updated on 2-Nov-2024

    Summary

    Official Symbol
    PAIP2provided by HGNC
    Official Full Name
    poly(A) binding protein interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17970
    See related
    Ensembl:ENSG00000120727 MIM:605604; AllianceGenome:HGNC:17970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAIP-2; PAIP2A
    Summary
    Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 45.2), adrenal (RPKM 41.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PAIP2 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139341854..139369717)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139867910..139895795)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138677543..138705406)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene matrin 3 Neighboring gene Sharpr-MPRA regulatory region 13556 Neighboring gene RNA, 5S ribosomal pseudogene 195 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:138657767-138658966 Neighboring gene RN7SK pseudogene 64 Neighboring gene solute carrier family 23 member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138716531-138717471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138723739-138724286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724287-138724834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724835-138725382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16409 Neighboring gene Sharpr-MPRA regulatory region 996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16411 Neighboring gene spermatogenesis associated 24 Neighboring gene marginal zone B and B1 cell specific protein Neighboring gene proline rich basic protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC72018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA binding  
    enables mRNA regulatory element binding translation repressor activity  
    enables protein binding PubMed 
    enables translation repressor activity  
    enables translation repressor activity PubMed 
    Process Evidence Code Pubs
    involved_in memory  
    involved_in negative regulation of translation  
    involved_in negative regulation of translational initiation PubMed 
    involved_in regulation of long-term synaptic potentiation  
    involved_in spermatogenesis  
    involved_in translation  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 

    General protein information

    Preferred Names
    polyadenylate-binding protein-interacting protein 2
    Names
    PABC1-interacting protein 2
    PABP-interacting protein 2
    polyA-binding protein-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033112.3NP_001028284.1  polyadenylate-binding protein-interacting protein 2

      See identical proteins and their annotated locations for NP_001028284.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC039337, BC062718, BU732743
      Consensus CDS
      CCDS4211.1
      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Related
      ENSP00000422508.1, ENST00000510080.1
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    2. NM_016480.5NP_057564.3  polyadenylate-binding protein-interacting protein 2

      See identical proteins and their annotated locations for NP_057564.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC039337, BI552800, BU732743
      Consensus CDS
      CCDS4211.1
      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Related
      ENSP00000265192.4, ENST00000265192.9
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region

    RNA

    1. NR_109830.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC039337, BI552800, BU732743

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      139341854..139369717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009522.2XP_016865011.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Related
      ENSP00000378275.2, ENST00000394795.6
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    2. XM_011543428.2XP_011541730.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011541730.1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    3. XM_047417265.1XP_047273221.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    4. XM_047417266.1XP_047273222.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    5. XM_017009523.3XP_016865012.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      139867910..139895795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352722.1XP_054208697.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    2. XM_054352723.1XP_054208698.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    3. XM_054352724.1XP_054208699.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    4. XM_054352725.1XP_054208700.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
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