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    TMEM245 transmembrane protein 245 [ Homo sapiens (human) ]

    Gene ID: 23731, updated on 14-Nov-2024

    Summary

    Official Symbol
    TMEM245provided by HGNC
    Official Full Name
    transmembrane protein 245provided by HGNC
    Primary source
    HGNC:HGNC:1363
    See related
    Ensembl:ENSG00000106771 MIM:620252; AllianceGenome:HGNC:1363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CG2; CG-2; C9orf5
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 48.4), adrenal (RPKM 29.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM245 in Genome Data Viewer
    Location:
    9q31.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (109015135..109119947, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (121184210..121289014, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (111777415..111882227, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20160 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:111713956-111715155 Neighboring gene actin binding transcription modulator Neighboring gene catenin alpha like 1 Neighboring gene uncharacterized LOC105376216 Neighboring gene RNA, 5.8S ribosomal pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:111774967-111775470 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:111798078-111799277 Neighboring gene microRNA 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20164 Neighboring gene ferric chelate reductase 1 like Neighboring gene Sharpr-MPRA regulatory region 1434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:111947797-111948296 Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene RNA, U6 small nuclear 984, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Whole genome association scan for genetic polymorphisms influencing information processing speed.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ23668, FLJ33224

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane PubMed 

    General protein information

    Preferred Names
    transmembrane protein 245
    Names
    protein CG-2
    transmembrane protein C9orf5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032012.4NP_114401.2  transmembrane protein 245

      See identical proteins and their annotated locations for NP_114401.2

      Status: VALIDATED

      Source sequence(s)
      AL354797, AL358815, AL556162, BC014248, BE675782, BM817899, BP351493, BP360669, DC341553
      Consensus CDS
      CCDS43858.1
      UniProtKB/Swiss-Prot
      B4DSW7, Q5JTQ5, Q5SS43, Q6ZME3, Q8NDJ5, Q96CG6, Q9H330
      Related
      ENSP00000363714.3, ENST00000374586.8
      Conserved Domains (1) summary
      cl00465
      Location:594840
      AI-2E_transport; AI-2E family transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      109015135..109119947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423140.1XP_047279096.1  transmembrane protein 245 isoform X7

    2. XM_011518449.3XP_011516751.1  transmembrane protein 245 isoform X4

      Conserved Domains (1) summary
      cl00465
      Location:555801
      UPF0118; Domain of unknown function DUF20
    3. XM_047423142.1XP_047279098.1  transmembrane protein 245 isoform X10

    4. XM_017014572.2XP_016870061.1  transmembrane protein 245 isoform X9

    5. XM_011518452.3XP_011516754.1  transmembrane protein 245 isoform X8

      Conserved Domains (1) summary
      cl00465
      Location:516762
      UPF0118; Domain of unknown function DUF20
    6. XM_047423139.1XP_047279095.1  transmembrane protein 245 isoform X6

    7. XM_017014571.2XP_016870060.1  transmembrane protein 245 isoform X3

    8. XM_011518446.3XP_011516748.1  transmembrane protein 245 isoform X1

      Conserved Domains (1) summary
      cl00465
      Location:593839
      UPF0118; Domain of unknown function DUF20
    9. XM_011518451.2XP_011516753.1  transmembrane protein 245 isoform X5

      Conserved Domains (1) summary
      cl00465
      Location:551797
      UPF0118; Domain of unknown function DUF20
    10. XM_011518447.2XP_011516749.1  transmembrane protein 245 isoform X2

      UniProtKB/TrEMBL
      H7C0G1
      Related
      ENSP00000394798.3, ENST00000413712.7
      Conserved Domains (1) summary
      cl00465
      Location:586832
      UPF0118; Domain of unknown function DUF20

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      121184210..121289014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362596.1XP_054218571.1  transmembrane protein 245 isoform X7

    2. XM_054362593.1XP_054218568.1  transmembrane protein 245 isoform X4

    3. XM_054362599.1XP_054218574.1  transmembrane protein 245 isoform X10

    4. XM_054362598.1XP_054218573.1  transmembrane protein 245 isoform X9

    5. XM_054362597.1XP_054218572.1  transmembrane protein 245 isoform X8

    6. XM_054362595.1XP_054218570.1  transmembrane protein 245 isoform X6

    7. XM_054362592.1XP_054218567.1  transmembrane protein 245 isoform X3

    8. XM_054362590.1XP_054218565.1  transmembrane protein 245 isoform X1

    9. XM_054362594.1XP_054218569.1  transmembrane protein 245 isoform X5

    10. XM_054362591.1XP_054218566.1  transmembrane protein 245 isoform X2

      UniProtKB/TrEMBL
      H7C0G1

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