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    MSI2 musashi RNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 124540, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MSI2provided by HGNC
    Official Full Name
    musashi RNA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:18585
    See related
    Ensembl:ENSG00000153944 MIM:607897; AllianceGenome:HGNC:18585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSI2H
    Summary
    This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in adrenal (RPKM 11.7), ovary (RPKM 7.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MSI2 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (57255851..57701581)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (58130926..58574836)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55333212..55762050)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:55156412-55157150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8744 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55163183-55163685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55168773-55169322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55170245-55170744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55186230-55186831 Neighboring gene Sharpr-MPRA regulatory region 9462 Neighboring gene AKAP1 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55213025-55213556 Neighboring gene MPRA-validated peak2909 silencer Neighboring gene A-kinase anchoring protein 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:55273397-55274596 Neighboring gene uncharacterized LOC101927510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12427 Neighboring gene NANOG hESC enhancer GRCh37_chr17:55337123-55337646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12428 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55365995-55366170 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55415927-55416094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12430 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55441475-55441718 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55456920-55457574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55478625-55479135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55488073-55488574 Neighboring gene MPRA-validated peak2912 silencer Neighboring gene Sharpr-MPRA regulatory region 14735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12434 Neighboring gene Sharpr-MPRA regulatory region 3702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12439 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55548443-55549306 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55549307-55550170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55562836-55563732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55573395-55573896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55584063-55584590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55588381-55588975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55588976-55589569 Neighboring gene uncharacterized LOC101927557 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:55601094-55602293 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:55605169-55606001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12442 Neighboring gene uncharacterized LOC107984993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12443 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55638731-55639231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55656316-55656816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55656817-55657317 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:55665351-55665880 Neighboring gene uncharacterized LOC101927539 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55680421-55680920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55682575-55683470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12444 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55685282-55685876 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55685877-55686469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55716402-55717204 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55720638-55720787 Neighboring gene RNA, 7SL, cytoplasmic 449, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55726383-55727192 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55740323-55740615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55741794-55742400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55753573-55754072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55785092-55785592 Neighboring gene RNA, U7 small nuclear 134 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55804275-55804774 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55805921-55806176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12446 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55813992-55814170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55828159-55828658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55838959-55839579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55839580-55840199 Neighboring gene MPRA-validated peak2914 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8751 Neighboring gene coiled-coil domain containing 182 Neighboring gene RN7SK pseudogene 94

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia. Zhang J, et al. Blood, 2024 Jan 25. PMID 37801708
    2. Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway. Zhang H, et al. Exp Cell Res, 2014 Jan 1. PMID 24076374
    3. RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer. Li M, et al. J Exp Clin Cancer Res, 2020 May 24. PMID 32448269, Free PMC Article
    4. MSI2 expression is decreased in grade II of gastric carcinoma. Emadi-Baygi M, et al. Pathol Res Pract, 2013 Nov. PMID 24002004
    5. Integrated genetic and epigenetic analyses uncover MSI2 association with allergic inflammation. Kim KW, et al. J Allergy Clin Immunol, 2021 Apr. PMID 32795589

    See all (157) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration.
      Title: Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration.
    2. Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia.
      Title: Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia.
    3. Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.
      Title: Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.
    4. The TGF-beta/Smad2/3 signaling pathway is involved in Musashi2-induced invasion and metastasis of colorectal cancer.
      Title: The TGF-β/Smad(2/3) signaling pathway is involved in Musashi2-induced invasion and metastasis of colorectal cancer.
    5. Prognostic value of MSI2 expression in human malignancies: A PRISMA-compliant meta-analysis.
      Title: Prognostic value of MSI2 expression in human malignancies: A PRISMA-compliant meta-analysis.
    6. Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the musashi RNA-binding protein 2/oestrogen receptor alpha 1 axis.
      Title: Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the musashi RNA-binding protein 2/oestrogen receptor alpha 1 axis.
    7. TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.
      Title: TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.
    8. Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.
      Title: Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.
    9. MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways.
      Title: MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways.
    10. Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.
      Title: Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.
    Submit: New GeneRIF Correction See all GeneRIFs (84)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetics of coronary artery calcification among African Americans, a meta-analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3245, FLJ36569

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein Musashi homolog 2
    Names
    musashi homolog 2
    musashi-2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322250.2 → NP_001309179.1  RNA-binding protein Musashi homolog 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC005325, AI416968, AK295060
      Consensus CDS
      CCDS82168.1
      UniProtKB/TrEMBL
      A0A6Q8PF05, B4DHE8
      Related
      ENSP00000414671.2, ENST00000416426.6
      Conserved Domains (3) summary
      TIGR01628
      Location:13 → 321
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:89 → 162
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cl17169
      Location:1 → 87
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001322251.2 → NP_001309180.1  RNA-binding protein Musashi homolog 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC007431, AC015883, AC091181
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    3. NM_138962.4 → NP_620412.1  RNA-binding protein Musashi homolog 2 isoform a

      See identical proteins and their annotated locations for NP_620412.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript, and encodes the longer isoform (a).
      Source sequence(s)
      AC005325, AC015883, AC091181, AI416968, BC001526
      Consensus CDS
      CCDS11596.1
      UniProtKB/Swiss-Prot
      Q7Z6M7, Q8N9T4, Q96DH6
      UniProtKB/TrEMBL
      A0A6Q8PF05
      Related
      ENSP00000284073.2, ENST00000284073.7
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    4. NM_170721.2 → NP_733839.1  RNA-binding protein Musashi homolog 2 isoform b

      See identical proteins and their annotated locations for NP_733839.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' UTR and coding region, compared to variant 1. The resulting isoform (b) contains distinct N- and C-termini compared to isoform a.
      Source sequence(s)
      AC007431, AC015883, AC091181
      Consensus CDS
      CCDS11597.1
      UniProtKB/Swiss-Prot
      Q96DH6
      Related
      ENSP00000313616.3, ENST00000322684.7
      Conserved Domains (2) summary
      cd12323
      Location:107 → 180
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:18 → 93
      RRM1_MSI2; RNA recognition motif 1 in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      57255851..57701581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435313.1 → XP_047291269.1  RNA-binding protein Musashi homolog 2 isoform X5

    2. XM_047435314.1 → XP_047291270.1  RNA-binding protein Musashi homolog 2 isoform X5

    3. XM_005257015.4 → XP_005257072.1  RNA-binding protein Musashi homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_005257072.1

      UniProtKB/TrEMBL
      A0A6Q8PF05
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    4. XM_047435311.1 → XP_047291267.1  RNA-binding protein Musashi homolog 2 isoform X2

    5. XM_047435312.1 → XP_047291268.1  RNA-binding protein Musashi homolog 2 isoform X3

    6. XM_017024148.2 → XP_016879637.1  RNA-binding protein Musashi homolog 2 isoform X4

    7. XM_047435315.1 → XP_047291271.1  RNA-binding protein Musashi homolog 2 isoform X6

    8. XM_047435316.1 → XP_047291272.1  RNA-binding protein Musashi homolog 2 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      58130926..58574836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314985.1 → XP_054170960.1  RNA-binding protein Musashi homolog 2 isoform X5

    2. XM_054314986.1 → XP_054170961.1  RNA-binding protein Musashi homolog 2 isoform X5

    3. XM_054314981.1 → XP_054170956.1  RNA-binding protein Musashi homolog 2 isoform X1

    4. XM_054314982.1 → XP_054170957.1  RNA-binding protein Musashi homolog 2 isoform X2

    5. XM_054314983.1 → XP_054170958.1  RNA-binding protein Musashi homolog 2 isoform X3

    6. XM_054314984.1 → XP_054170959.1  RNA-binding protein Musashi homolog 2 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96DH6.1 GenPept UniProtKB/Swiss-Prot:Q96DH6

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