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    ZFP42 ZFP42 zinc finger protein [ Homo sapiens (human) ]

    Gene ID: 132625, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZFP42provided by HGNC
    Official Full Name
    ZFP42 zinc finger proteinprovided by HGNC
    Primary source
    HGNC:HGNC:30949
    See related
    Ensembl:ENSG00000179059 MIM:614572; AllianceGenome:HGNC:30949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    REX1; REX-1; ZNF754; zfp-42
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Involved in female gonad development and male gonad development. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 1.0), placenta (RPKM 0.5) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See ZFP42 in Genome Data Viewer
    Location:
    4q35.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (187995771..188005246)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (191341992..191352990)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (188916925..188926200)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900880 Neighboring gene uncharacterized LOC124900881 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:188894922-188895422 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188916113-188917092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188917093-188918074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188942947-188943484 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188953065-188953586 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188953587-188954108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:188962925-188963778 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:189002377-189002958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:189021213-189021714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189027714-189028231 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189028751-189029269 Neighboring gene tripartite motif family like 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189029270-189029788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189033421-189033938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:189033939-189034456 Neighboring gene uncharacterized LOC107986337 Neighboring gene FAU pseudogene 3 Neighboring gene RNA, U6 small nuclear 173, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens. Henderson JK, et al. Stem Cells, 2002. PMID 12110702
    2. The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. Mongan NP, et al. Mol Carcinog, 2006 Dec. PMID 16865673
    3. Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. Lee MY, et al. J Cell Physiol, 2010 Jul. PMID 20232320, Free PMC Article
    4. Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells. Lin YC, et al. Stem Cell Res Ther, 2014. PMID 25157408, Free PMC Article
    5. Cobalt chloride supplementation induces stem-cell marker expression and inhibits osteoblastic differentiation in human periodontal ligament cells. Osathanon T, et al. Arch Oral Biol, 2015 Jan. PMID 25244616

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. REX-1 Represses RASSF1a and Activates the MEK/ERK Pathway to Promote Tumorigenesis in Prostate Cancer.
      Title: REX-1 Represses RASSF1a and Activates the MEK/ERK Pathway to Promote Tumorigenesis in Prostate Cancer.
    2. REX1 overexpression could play a crucial role in the metastasis and invasion of cervical cancer by upregulating the activity of the JAK2/STAT3 pathway by trans-suppressing SOCS1 expression.
      Title: REX1 promotes EMT-induced cell metastasis by activating the JAK2/STAT3-signaling pathway by targeting SOCS1 in cervical cancer.
    3. ZFP42 missense mutation was identified in patients with multilocus imprinting disturbances. ZFP42 pathogenic mutation affects protein conformation and activity.
      Title: Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders.
    4. Results provide evidence that bFGF regulates stemness maintenance in stem cells isolated from human exfoliated deciduous teeth (SHEDs) by enhancing REX-1 mRNA expression via the FGFR and Akt signaling pathways. Moreover, IL-6 is also involved in the bFGF-induced REX1 expression.
      Title: Basic Fibroblast Growth Factor Regulates REX1 Expression Via IL-6 In Stem Cells Isolated From Human Exfoliated Deciduous Teeth.
    5. Results show that a novel pluripotency regulator, REX1, is essential for pluripotency and reprogramming.
      Title: Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency.
    6. reduced expression protein-1 (REX-1) is widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination.
      Title: Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination.
    7. hRex1 binds to the hRex1 promoter region at -298 bp and positively regulates hRex1 transcription, but this regulation is lost in PC-3 human prostate cancer cells.
      Title: Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells.
    8. expression of REX-1 in meiotic cells from both testes and ovary indicate a role in meiosis.
      Title: Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms.
    9. REX1 functions in normal adult epithelial cells and tumorigenic stem cells.
      Title: The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures.
    10. Data show that Oct-4, Rex-1, and Gata-4 expression in human mesenchymal stem cells increases cell differentiation efficiency but not hTERT expression.
      Title: Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 42 homolog
    Names
    REX1 transcription factor
    reduced expression protein 1
    zinc finger protein 754

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304358.2 → NP_001291287.1  zinc finger protein 42 homolog

      See identical proteins and their annotated locations for NP_001291287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA641545, AC108073, AK056719
      Consensus CDS
      CCDS3849.1
      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3
      Related
      ENSP00000424662.1, ENST00000509524.5
      Conserved Domains (3) summary
      COG5048
      Location:214 → 307
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:219 → 239
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:232 → 257
      zf-H2C2_2; Zinc-finger double domain

    2. NM_174900.5 → NP_777560.2  zinc finger protein 42 homolog

      See identical proteins and their annotated locations for NP_777560.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA641545, AC108073, AY429593
      Consensus CDS
      CCDS3849.1
      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3
      Related
      ENSP00000317686.4, ENST00000326866.5
      Conserved Domains (3) summary
      COG5048
      Location:214 → 307
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:219 → 239
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:232 → 257
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      187995771..188005246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531606.2 → XP_011529908.1  zinc finger protein 42 homolog isoform X1

      See identical proteins and their annotated locations for XP_011529908.1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3
      Conserved Domains (3) summary
      COG5048
      Location:214 → 307
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:219 → 239
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:232 → 257
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011531605.2 → XP_011529907.1  zinc finger protein 42 homolog isoform X1

      See identical proteins and their annotated locations for XP_011529907.1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3
      Conserved Domains (3) summary
      COG5048
      Location:214 → 307
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:219 → 239
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:232 → 257
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011531604.3 → XP_011529906.1  zinc finger protein 42 homolog isoform X1

      See identical proteins and their annotated locations for XP_011529906.1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3
      Conserved Domains (3) summary
      COG5048
      Location:214 → 307
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:219 → 239
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:232 → 257
      zf-H2C2_2; Zinc-finger double domain

    4. XM_047449603.1 → XP_047305559.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3

    5. XM_047449602.1 → XP_047305558.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      191341992..191352990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348912.1 → XP_054204887.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3

    2. XM_054348910.1 → XP_054204885.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3

    3. XM_054348911.1 → XP_054204886.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3

    4. XM_054348908.1 → XP_054204883.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3

    5. XM_054348909.1 → XP_054204884.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3

    6. XM_054348907.1 → XP_054204882.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3

    7. XM_054348906.1 → XP_054204881.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      D3DP65, Q8WXE2, Q96MM3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96MM3.2 GenPept UniProtKB/Swiss-Prot:Q96MM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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