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    UBA1 E1 ubiquitin-activating protein UBA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853670, updated on 2-Nov-2024

    Summary

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    Official Symbol
    UBA1
    Official Full Name
    E1 ubiquitin-activating protein UBA1
    Primary source
    SGD:S000001693
    Locus tag
    YKL210W
    See related
    AllianceGenome:SGD:S000001693; FungiDB:YKL210W; VEuPathDB:YKL210W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin activating enzyme activity. Involved in protein ubiquitination. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to several human genes including UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See UBA1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (39163..42237)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase Neighboring gene ncRNA Neighboring gene ATP-binding cassette a-factor transporter STE6 Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome. Yu H, et al. J Biol Chem, 2016 Jul 8. PMID 27226608, Free PMC Article
    2. A viable ubiquitin-activating enzyme mutant for evaluating ubiquitin system function in Saccharomyces cerevisiae. Swanson R, et al. FEBS Lett, 2000 Jul 21. PMID 10908719
    3. Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast. Roscoe BP, et al. J Mol Biol, 2014 Jul 29. PMID 24862281, Free PMC Article
    4. Structural and Functional Characterisation of the Domains of Ubiquitin-Activating Enzyme (E1) of Saccharomyces cerevisiae. Panchamia B, et al. Cell Biochem Biophys, 2020 Sep. PMID 32583128
    5. UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme. McGrath JP, et al. EMBO J, 1991 Jan. PMID 1989885, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of UBA1 with one ubiquitin, which is bound in its adenylated form to the active adenylation domain of UBA1, and the the second ubiquitin is covalently linked to the active-site cysteine.
      Title: Structure of the ubiquitin-activating enzyme loaded with two ubiquitin molecules.
    2. isolation of uba1-204, a temperature-sensitive allele of the essential E1 gene, UBA1
      Title: A conditional yeast E1 mutant blocks the ubiquitin-proteasome pathway and reveals a role for ubiquitin conjugates in targeting Rad23 to the proteasome.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macromolecule modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E1 ubiquitin-activating protein UBA1
    NP_012712.1
    • Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      39163..42237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179775.1 → NP_012712.1  TPA: E1 ubiquitin-activating protein UBA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012712.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWZ3, P22515
      UniProtKB/TrEMBL
      G2WHI4, N1P0K4
      Conserved Domains (1) summary
      TIGR01408
      Location:13 → 1023
      Ube1; ubiquitin-activating enzyme E1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22515.2

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