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    LSB6 1-phosphatidylinositol 4-kinase LSB6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853345, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LSB6
    Official Full Name
    1-phosphatidylinositol 4-kinase LSB6
    Primary source
    SGD:S000003636
    Locus tag
    YJL100W
    See related
    AllianceGenome:SGD:S000003636; FungiDB:YJL100W; VEuPathDB:YJL100W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 1-phosphatidylinositol 4-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Located in fungal-type vacuole membrane and plasma membrane. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha) and PI4K2B (phosphatidylinositol 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See LSB6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (237263..239086)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene glutamate--cysteine ligase Neighboring gene Chs6p Neighboring gene Sap185p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae contains a Type II phosphoinositide 4-kinase. Shelton SN, et al. Biochem J, 2003 Apr 15. PMID 12523934, Free PMC Article
    2. Purification, characterization, and kinetic analysis of a 55-kDa form of phosphatidylinositol 4-kinase from Saccharomyces cerevisiae. Nickels JT Jr, et al. J Biol Chem, 1992 Aug 15. PMID 1322897
    3. Regulation of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae by CDP-diacylglycerol. Nickels JT Jr, et al. J Biol Chem, 1994 Apr 15. PMID 8157627
    4. Photoaffinity labeling of the 45-kDa and 55-kDa forms of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae. Nickels JT Jr, et al. J Biol Chem, 1993 Nov 15. PMID 8226954
    5. The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity. Han GS, et al. J Biol Chem, 2002 Dec 6. PMID 12361950

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol 4-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol 4-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4-kinase LSB6
    NP_012435.1
    • Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      237263..239086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181533.1 → NP_012435.1  TPA: 1-phosphatidylinositol 4-kinase LSB6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012435.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW84, P42951
      UniProtKB/TrEMBL
      B3LQ13, C8ZB63, N1P178
      Conserved Domains (1) summary
      pfam00454
      Location:170 → 498
      PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42951.1

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