bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Full Name: bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase
Primary source: SGD:S000000812
Locus tag: YER010C
See related: AllianceGenome:SGD:S000000812; FungiDB:YER010C; VEuPathDB:YER010C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity and oxaloacetate decarboxylase activity. Involved in 3,4-dihydroxybenzoate catabolic process. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxaloacetate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxaloacetate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxaloacetate decarboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3,4-dihydroxybenzoate catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

Preferred Names: bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase

NP_010926.3

Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate

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