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    HEM1 5-aminolevulinate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851818, updated on 2-Nov-2024

    Summary

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    Official Symbol
    HEM1
    Official Full Name
    5-aminolevulinate synthase
    Primary source
    SGD:S000002640
    Locus tag
    YDR232W
    See related
    AllianceGenome:SGD:S000002640; FungiDB:YDR232W; VEuPathDB:YDR232W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CYD1; OLE3
    Summary
    Enables 5-aminolevulinate synthase activity. Involved in heme biosynthetic process and positive regulation of organelle assembly. Located in mitochondrial matrix. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria; erythropoietic protoporphyria; hemochromatosis; sideroblastic anemia; and sideroblastic anemia 1. Orthologous to several human genes including ALAS2 (5'-aminolevulinate synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See HEM1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (927452..929098)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ivy1p Neighboring gene Cox20p Neighboring gene Rtn1p Neighboring gene homoaconitate hydratase LYS4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Posttranscriptional heme control of catalase synthesis in the yeast Saccharomyces cerevisiae. Sledziewski A, et al. Curr Genet, 1981 Sep. PMID 24185863
    2. Functional expression of a bacterial α-ketoglutarate dehydrogenase in the cytosol of Saccharomyces cerevisiae. Baldi N, et al. Metab Eng, 2019 Dec. PMID 31585168
    3. The nine amino-terminal residues of delta-aminolevulinate synthase direct beta-galactosidase into the mitochondrial matrix. Keng T, et al. Mol Cell Biol, 1986 Feb. PMID 3023841, Free PMC Article
    4. Cloning of the δ-aminolevulinic acid synthase structural gene in yeast. Arrese M, et al. Curr Genet, 1983 Jun. PMID 24173275
    5. The presequence of yeast 5-aminolevulinate synthase is not required for targeting to mitochondria. Volland C, et al. J Biol Chem, 1988 Jun 15. PMID 3286648

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the mitochondrial aminolevulinic acid synthase, a key heme biosynthetic enzyme, has been resolved.
      Title: Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme.
    2. Data show that in the hem1 deletion mutant a slight disordering effect on steryl esters was observed indicated by loss of the high temperature transition.
      Title: Influence of squalene on lipid particle/droplet and membrane organization in the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5-aminolevulinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-aminolevulinate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5-aminolevulinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5-aminolevulinate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of organelle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrapyrrole biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5-aminolevulinate synthase
    NP_010518.1
    • 5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p; has a pyridoxal phosphate cofactor whose insertion is mediated by Mcx1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      927452..929098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180540.1 → NP_010518.1  TPA: 5-aminolevulinate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSL3, E9P946, P09950
      UniProtKB/TrEMBL
      C7GVC1, C8Z5E3
      Conserved Domains (1) summary
      TIGR01821
      Location:71 → 492
      5aminolev_synth; 5-aminolevulinic acid synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09950.1

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