STP22 ubiquitin-binding ESCRT-I subunit protein STP22 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: STP22
Official Full Name: ubiquitin-binding ESCRT-I subunit protein STP22
Primary source: SGD:S000000514
Locus tag: YCL008C
See related: AllianceGenome:SGD:S000000514; FungiDB:YCL008C; VEuPathDB:YCL008C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AGS1; VPL15; VPS23
Summary: Enables ubiquitin binding activity. Involved in several processes, including ATP export; protein targeting; and reticulophagy. Located in cytoplasmic side of plasma membrane and endosome. Part of ESCRT I complex. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to several human genes including TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See STP22 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (105696..106853, complement)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSDP motifs of the Vps27 ESCRT-0 subunit bind to a novel electropositive N-terminal site on the UEV domain of the ESCRT-I subunit Vps23 centred on Trp16.
Title: Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast.
found that in Saccharomyces cerevisiae, Rim8 binds to both the putative seven-transmembrane pH sensor Rim21 and the ESCRT-I subunit Vps23.
Title: Recruitment of the ESCRT machinery to a putative seven-transmembrane-domain receptor is mediated by an arrestin-related protein.
The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37.
Title: Structural and functional organization of the ESCRT-I trafficking complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to vacuole	IEA Inferred from Electronic Annotation more info
involved_in late endosome to vacuole transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in reticulophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IDA Inferred from Direct Assay more info	PubMed
part_of ESCRT I complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-binding ESCRT-I subunit protein STP22

NP_009919.3

Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

105696..106853 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178657.1 → NP_009919.3 TPA: ubiquitin-binding ESCRT-I subunit protein STP22 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009919.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR04, P25604, P87010, P87279, Q86ZT3, Q8NIM6

UniProtKB/TrEMBL

B3LU67, B5VEU5, C8Z477, G2WA12, N1P808

Conserved Domains (2) summary

pfam05743
Location:31 → 156

UEV; UEV domain

pfam09454
Location:316 → 375

Vps23_core; Vps23 core domain