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    RIM1 Rim1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850395, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RIM1
    Official Full Name
    Rim1p
    Primary source
    SGD:S000007222
    Locus tag
    YCR028C-A
    See related
    AllianceGenome:SGD:S000007222; FungiDB:YCR028C-A; VEuPathDB:YCR028C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables single-stranded DNA binding activity. Involved in mitochondrial genome maintenance and positive regulation of mitochondrial DNA replication. Located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human SSBP1 (single stranded DNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RIM1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_001135.5 (172950..173440, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene Fen2p Neighboring gene Syp1p Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glucose repression on RIM1, a gene encoding a mitochondrial single-stranded DNA-binding protein, in Saccharomyces cerevisiae: a possible regulation at pre-mRNA splicing. Li Z, et al. Curr Genet, 1998 Dec. PMID 9871116
    2. A single-stranded DNA binding protein required for mitochondrial DNA replication in S. cerevisiae is homologous to E. coli SSB. Van Dyck E, et al. EMBO J, 1992 Sep. PMID 1324172, Free PMC Article
    3. Analysis of Protein-protein Interaction Interface between Yeast Mitochondrial Proteins Rim1 and Pif1 Using Chemical Cross-linking Mass Spectrometry. Zybailov B, et al. J Proteomics Bioinform, 2015 Nov. PMID 26807012, Free PMC Article
    4. Physical and functional interaction between yeast Pif1 helicase and Rim1 single-stranded DNA binding protein. Ramanagoudr-Bhojappa R, et al. Nucleic Acids Res, 2013 Jan. PMID 23175612, Free PMC Article
    5. The mitochondrial single-stranded DNA binding protein from S. cerevisiae, Rim1, does not form stable homo-tetramers and binds DNA as a dimer of dimers. Singh SP, et al. Nucleic Acids Res, 2018 Aug 21. PMID 29931186, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show a direct physical interaction between Pif1 helicase and Rim1 regulated by two binding regions on each of the proteins.
      Title: Physical and functional interaction between yeast Pif1 helicase and Rim1 single-stranded DNA binding protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial nucleoid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rim1p
    NP_009958.2
    • ssDNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; stimulates utilization by Mip1p DNA polymerase of RNA primers synthesized by Rpo41p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      172950..173440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184315.1 → NP_009958.2  TPA: Rim1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009958.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR39, O11851, P32445
      UniProtKB/TrEMBL
      A6ZTL0, B3LUA0, C7GQ17, G2WA47, N1P844
      Conserved Domains (1) summary
      pfam00436
      Location:19 → 116
      SSB; Single-strand binding protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32445.1

    Gene LinkOut

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