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    PYC2 pyruvate carboxylase 2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852519, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PYC2
    Official Full Name
    pyruvate carboxylase 2
    Primary source
    SGD:S000000422
    Locus tag
    YBR218C
    See related
    AllianceGenome:SGD:S000000422; FungiDB:YBR218C; VEuPathDB:YBR218C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pyruvate carboxylase activity. Involved in gluconeogenesis. Located in cytosol. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PYC2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (658707..662249, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ybp1p Neighboring gene Atg12p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of pyc1 encoding pyruvate carboxylase isozyme I by nitrogen sources in Saccharomyces cerevisiae. Huet C, et al. Eur J Biochem, 2000 Dec. PMID 11082192
    2. Pyruvate carboxylase. Specific inactivation of acetyl coenzyme A-dependent oxylacetate synthesis during modification of the enzyme by trinitrobenzene sulfonate. Scrutton MC, et al. J Biol Chem, 1973 Aug 10. PMID 4588687
    3. Human genetic diseases: a cross-talk between man and yeast. Foury F. Gene, 1997 Aug 11. PMID 9300813
    4. Regulation of pyruvate carboxylase isozyme (PYC1, PYC2) gene expression in Saccharomyces cerevisiae during fermentative and nonfermentative growth. Brewster NK, et al. Arch Biochem Biophys, 1994 May 15. PMID 8185321
    5. Regulatory regions in the promoters of the Saccharomyces cerevisiae PYC1 and PYC2 genes encoding isoenzymes of pyruvate carboxylase. Menéndez J, et al. FEMS Microbiol Lett, 1998 Jul 15. PMID 9682484

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small molecule biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate carboxylase 2
    NP_009777.1
    • Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      658707..662249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178566.1 → NP_009777.1  TPA: pyruvate carboxylase 2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009777.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQL4, P32327
      UniProtKB/TrEMBL
      A6ZLF8, B3LMU2, G2W9M1
      Conserved Domains (1) summary
      COG1038
      Location:15 → 1171
      PycA; Pyruvate carboxylase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32327.2

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