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    PFF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852366, updated on 22-Aug-2024

    Summary

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    Official Symbol
    PFF1
    Primary source
    FungiDB:YBR074W
    Locus tag
    YBR074W
    See related
    SGD:S000000278; AllianceGenome:SGD:S000000278; VEuPathDB:YBR074W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YBR075W
    Summary
    Predicted to enable metal ion binding activity and metalloexopeptidase activity. Predicted to be involved in proteolysis. Located in fungal-type vacuole membrane. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (386286..389216)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA-dependent ATPase RDH54 Neighboring gene Ecm8p Neighboring gene Slm4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes. Fitzpatrick DA, et al. PLoS One, 2011. PMID 22194885, Free PMC Article
    2. Characterization of an M28 metalloprotease family member residing in the yeast vacuole. Hecht KA, et al. FEMS Yeast Res, 2013 Aug. PMID 23679341, Free PMC Article
    3. Enhanced peptide secretion by gene disruption of CYM1, a novel protease in Saccharomyces cerevisiae. Jønson L, et al. Eur J Biochem, 2004 Dec. PMID 15606766
    4. Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner. Boutouja F, et al. Sci Rep, 2019 Jul 22. PMID 31332264, Free PMC Article
    5. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloexopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pff1p
    NP_009630.3
    • Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to M28 family of metalloproteases; has lumenal-facing protease domain; proposed role in vacuole physiology; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      386286..389216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178422.2 → NP_009630.3  TPA: Pff1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009630.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ74, P38244, P38245, Q86ZS2
      UniProtKB/TrEMBL
      G2W980, N1P8C2
      Conserved Domains (2) summary
      cd03875
      Location:50 → 354
      M28_Fxna_like; M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1
      cl02291
      Location:366 → 443
      DUF2189; Predicted integral membrane protein (DUF2189)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38244.3

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