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    CUR1 Cur1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856281, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CUR1
    Official Full Name
    Cur1p
    Primary source
    SGD:S000006362
    Locus tag
    YPR158W
    See related
    AllianceGenome:SGD:S000006362; FungiDB:YPR158W; VEuPathDB:YPR158W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-folding chaperone binding activity. Involved in intracellular protein transport; protein folding; and protein localization to nucleus. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CUR1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (843262..844020)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene spermine transporter Neighboring gene Tda6p Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene gag-pol fusion protein Neighboring gene gag protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Curing of the [URE3] prion by Btn2p, a Batten disease-related protein. Kryndushkin DS, et al. EMBO J, 2008 Oct 22. PMID 18833194, Free PMC Article
    2. Mutations Outside the Ure2 Amyloid-Forming Region Disrupt [URE3] Prion Propagation and Alter Interactions with Protein Quality Control Factors. Kumar S, et al. Mol Cell Biol, 2020 Oct 13. PMID 32868289, Free PMC Article
    3. Antiprion systems in yeast cooperate to cure or prevent the generation of nearly all [PSI(+)] and [URE3] prions. Son M, et al. Proc Natl Acad Sci U S A, 2022 Jul 12. PMID 35787049, Free PMC Article
    4. To CURe or not to CURe? Differential effects of the chaperone sorting factor Cur1 on yeast prions are mediated by the chaperone Sis1. Barbitoff YA, et al. Mol Microbiol, 2017 Jul. PMID 28431189
    5. Real-time imaging of yeast cells reveals several distinct mechanisms of curing of the [URE3] prion. Zhao X, et al. J Biol Chem, 2018 Mar 2. PMID 29330300, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteasome Control of [URE3] Prion Propagation by Degradation of Anti-Prion Proteins Cur1 and Btn2 in Saccharomyces cerevisiae.
      Title: Proteasome Control of [URE3] Prion Propagation by Degradation of Anti-Prion Proteins Cur1 and Btn2 in Saccharomyces cerevisiae.
    2. Innate immunity to yeast prions: Btn2p and Cur1p curing of the [URE3] prion is prevented by 60S ribosomal protein deficiency or ubiquitin/proteasome system overactivity.
      Title: Innate immunity to yeast prions: Btn2p and Cur1p curing of the [URE3] prion is prevented by 60S ribosomal protein deficiency or ubiquitin/proteasome system overactivity.
    3. Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants.
      Title: Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants.
    4. Protein redistribution by Btn2 is accompanied by a gradual depletion of Sis1 from the cytosol, which is mediated by the sorting factor Cur1.
      Title: Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cur1p
    NP_015484.1
    • Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      843262..844020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184255.1 → NP_015484.1  TPA: Cur1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015484.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4F4, Q06469
      UniProtKB/TrEMBL
      A6ZX33, B3LKB8, B5VTU2, C8ZJI1, N1NXU6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06469.1

    Gene LinkOut

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