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    EGD1 Egd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856070, updated on 2-Nov-2024

    Summary

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    Official Symbol
    EGD1
    Official Full Name
    Egd1p
    Primary source
    SGD:S000005958
    Locus tag
    YPL037C
    See related
    AllianceGenome:SGD:S000005958; FungiDB:YPL037C; VEuPathDB:YPL037C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in cotranslational protein targeting to membrane and macroautophagy. Acts upstream of or within mitophagy. Part of nascent polypeptide-associated complex. Orthologous to human BTF3 (basic transcription factor 3) and BTF3L4 (basic transcription factor 3 like 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See EGD1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (481428..481901, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Met31p Neighboring gene H(+)-exporting P2-type ATPase PMA2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The EGD1 product, a yeast homolog of human BTF3, may be involved in GAL4 DNA binding. Parthun MR, et al. Mol Cell Biol, 1992 Dec. PMID 1448098, Free PMC Article
    2. Yeast BTF3 protein is encoded by duplicated genes and inhibits the expression of some genes in vivo. Hu GZ, et al. Nucleic Acids Res, 1994 Jul 25. PMID 8052529, Free PMC Article
    3. The yeast EGD2 gene encodes a homologue of the alpha NAC subunit of the human nascent-polypeptide-associated complex. Shi X, et al. Gene, 1995 Nov 20. PMID 8522175
    4. Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast. Franke J, et al. J Cell Sci, 2001 Jul. PMID 11683391
    5. The nascent polypeptide-associated complex subunit Egd1 is required for efficient selective mitochondrial degradation in budding yeast. Tian Y, et al. Sci Rep, 2024 Jan 4. PMID 38177147, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The nascent polypeptide-associated complex subunit Egd1 is required for efficient selective mitochondrial degradation in budding yeast.
      Title: The nascent polypeptide-associated complex subunit Egd1 is required for efficient selective mitochondrial degradation in budding yeast.
    2. Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
      Title: Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
    3. Study reports that EGD1 mRNA is localized in a novel cytoplasmic inclusion, named EGD1 granule, when EGD1 is expressed excessively compared to EGD2 in S. cerevisiae.
      Title: EGD1 (β-NAC) mRNA is localized in a novel cytoplasmic structure in Saccharomyces cerevisiae.
    4. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
      Title: Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cotranslational protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Egd1p
    NP_015288.1
    • Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting to mitochondria; peripheral component of cytoplasmic ribosomes; regulates Atg32p phosphorylation to promote respiration-induced mitophagy; enhances DNA binding of the Gal4p; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      481428..481901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183851.1 → NP_015288.1  TPA: Egd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZWL1, D6W3X7, Q02107, Q02642
      UniProtKB/TrEMBL
      B3LL28, C7GU17, C8ZIZ2, G2WPE2, N1NXB6
      Conserved Domains (1) summary
      cd22055
      Location:9 → 125
      NAC_BTF3; basal transcription factor BTF3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02642.2

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