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    GCR2 Gcr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855522, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GCR2
    Official Full Name
    Gcr2p
    Primary source
    SGD:S000005143
    Locus tag
    YNL199C
    See related
    AllianceGenome:SGD:S000005143; FungiDB:YNL199C; VEuPathDB:YNL199C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coregulator activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of antisense RNA transcription; and positive regulation of ribosomal protein gene transcription by RNA polymerase II. Located in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GCR2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (264926..266530, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Psy2p Neighboring gene NADHX epimerase Neighboring gene mRNA-binding protein WHI3 Neighboring gene Slz1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic Changes Induced by Deletion of Transcriptional Regulator GCR2 in Xylose-Fermenting Saccharomyces cerevisiae. Shin M, et al. Microorganisms, 2020 Sep 29. PMID 33003408, Free PMC Article
    2. The GCR2 gene is required for the transcriptional activation of retrotransposon Ty2-917 in Saccharomyces cerevisiae. Türkel S. Biol Pharm Bull, 2002 Sep. PMID 12230120
    3. Transcriptomic Changes Induced by Deletion of Transcriptional Regulator GCR2 on Pentose Sugar Metabolism in Saccharomyces cerevisiae. Shin M, et al. Front Bioeng Biotechnol, 2021. PMID 33842449, Free PMC Article
    4. Influence of low glycolytic activities in gcr1 and gcr2 mutants on the expression of other metabolic pathway genes in Saccharomyces cerevisiae. Sasaki H, et al. Yeast, 2005 Jan 30. PMID 15645478
    5. The E-box DNA binding protein Sgc1p suppresses the gcr2 mutation, which is involved in transcriptional activation of glycolytic genes in Saccharomyces cerevisiae. Sato T, et al. FEBS Lett, 1999 Dec 17. PMID 10606743

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antisense RNA transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of antisense RNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gcr2p
    NP_014200.1
    • Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      264926..266530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183037.1 → NP_014200.1  TPA: Gcr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014200.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Y9, Q01722
      UniProtKB/TrEMBL
      A6ZRN9, C7GTG9, G2WLR2, N1NZ81
      Conserved Domains (1) summary
      PHA03255
      Location:30 → 131
      PHA03255; BDLF3; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01722.1

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