NUP53 FG-nucleoporin NUP53 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NUP53
Official Full Name: FG-nucleoporin NUP53
Primary source: SGD:S000004762
Locus tag: YMR153W
See related: AllianceGenome:SGD:S000004762; FungiDB:YMR153W; VEuPathDB:YMR153W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phospholipid binding activity and single-stranded DNA binding activity. A structural constituent of nuclear pore. Involved in several processes, including nuclear pore organization; protein localization to organelle; and regulation of protein desumoylation. Part of nuclear pore central transport channel and nuclear pore nuclear basket. Orthologous to human NUP35 (nucleoporin 35). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NUP53 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (564435..565862)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Nup53.Kap121 complex forms an ensemble of structures that destabilize Nup53 hub interactions.
Title: Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions.
NUP53 is a target of CDK1 and HRR25.
Title: Nup53p is a target of two mitotic kinases, Cdk1p and Hrr25p.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in NLS-bearing protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic nuclear division	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein desumoylation	IPI Inferred from Physical Interaction more info	PubMed
involved_in response to spindle checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore central transport channel	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore nuclear basket	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FG-nucleoporin NUP53

NP_013873.1

FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

564435..565862

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182656.1 → NP_013873.1 TPA: FG-nucleoporin NUP53 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013873.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZX4, Q03790

UniProtKB/TrEMBL

G2WKK4

Conserved Domains (1) summary

cd12721
Location:250 → 347

RRM_Nup53p_fungi; RNA recognition motif (RRM) found in yeast nucleoporin Nup53p and similar proteins