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    Chchd2l3 coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316643, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Chchd2l3provided by RGD
    Official Full Name
    coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 3provided by RGD
    Primary source
    RGD:1309819
    See related
    EnsemblRapid:ENSRNOG00000051180 AllianceGenome:RGD:1309819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Chchd2; Scand3-ps1
    Summary
    Predicted to enable DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Predicted to be involved in several processes, including cellular response to oxidative stress; positive regulation of mitochondrial ATP synthesis coupled electron transport; and regulation of cellular response to hypoxia. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 22. Orthologous to human CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    9q36
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101947769..101948440, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94500439..94501110, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (101388148..101388819, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene neuraminidase 4 Neighboring gene programmed cell death 1 Neighboring gene Set nuclear proto-oncogene, pseudogene 2 Neighboring gene NOC3-like DNA replication regulator, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study. Funayama M, et al. Lancet Neurol, 2015 Mar. PMID 25662902
    2. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. Aras S, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23303788, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112750

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial
    Names
    SCAN domain containing 3 pseudogene
    SCAN domain containing 3, pseudogene 1
    coiled-coil-helix-coiled-coil-helix domain containing 2
    coiled-coil-helix-coiled-coil-helix domain containing 2-like 3
    coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015019.2 → NP_001015019.2  coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R785
      Related
      ENSRNOP00000065307.1, ENSRNOT00000071817.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101947769..101948440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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