CST26 putative acyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CST26
Official Full Name: putative acyltransferase
Primary source: SGD:S000000246
Locus tag: YBR042C
See related: AllianceGenome:SGD:S000000246; FungiDB:YBR042C; VEuPathDB:YBR042C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PSI1
Summary: Enables acyltransferase activity. Involved in phosphatidylinositol acyl-chain remodeling. Located in lipid droplet. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3); AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4); and LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CST26 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (320416..321609, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast.
Title: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylinositol acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	HDA more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative acyltransferase

NP_009598.1

Acyltransferase; enzyme mainly responsible for the introduction of saturated very long chain fatty acids into neo-synthesized molecules of phosphatidylinositol; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

320416..321609 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178390.1 → NP_009598.1 TPA: putative acyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009598.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQ42, P38226

UniProtKB/TrEMBL

C7GXX0, G2W947, N1P802

Conserved Domains (2) summary

cd07990
Location:103 → 314

LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like

pfam16076
Location:300 → 372

Acyltransf_C; Acyltransferase C-terminus