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    HKR1 Hkr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852030, updated on 2-Nov-2024

    Summary

    Official Symbol
    HKR1
    Official Full Name
    Hkr1p
    Primary source
    SGD:S000002828
    Locus tag
    YDR420W
    See related
    AllianceGenome:SGD:S000002828; FungiDB:YDR420W; VEuPathDB:YDR420W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables osmosensor activity. Involved in several processes, including (1->3)-beta-D-glucan biosynthetic process; cellular bud site selection; and osmosensory signaling pathway via Sho1 osmosensor. Located in plasma membrane and site of polarized growth. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See HKR1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1306267..1311675)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase eta Neighboring gene tRNA-Ser Neighboring gene Aro80p Neighboring gene Sip1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables osmosensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables osmosensor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables osmosensor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in (1->3)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular bud site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hyperosmotic response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hyperosmotic response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in osmosensory signaling pathway via Sho1 osmosensor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in osmosensory signaling pathway via Sho1 osmosensor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osmosensory signaling pathway via Sho1 osmosensor IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in osmosensory signaling pathway via Sho1 osmosensor IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in signal transduction involved in filamentous growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Hkr1p
    NP_010708.1
    • Mucin family member that functions as an osmosensor in the HOG pathway; large, highly glycosylated protein that functions redundantly with Msb2p in Sho1p-mediated osmostresss induction of the HOG signaling pathway; cytoplasmic domain interacts with Ahk1p a scaffold protein that prevents cross talk with the Kss1p MAPK of the filamentous growth pathway; mutant displays defects in beta-1,3 glucan synthesis and bud site selection

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1306267..1311675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180728.1NP_010708.1  TPA: Hkr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010708.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT50, P41809, Q04051
      UniProtKB/TrEMBL
      G2WBF6
      Conserved Domains (2) summary
      PLN02217
      Location:397506
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      PHA03307
      Location:452776
      PHA03307; transcriptional regulator ICP4; Provisional