APA2 bifunctional AP-4-A phosphorylase/ADP sulfurylase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: APA2
Official Full Name: bifunctional AP-4-A phosphorylase/ADP sulfurylase
Primary source: SGD:S000002938
Locus tag: YDR530C
See related: AllianceGenome:SGD:S000002938; FungiDB:YDR530C; VEuPathDB:YDR530C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables bis(5'-nucleosyl)-tetraphosphatase activity. Involved in nucleoside catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See APA2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1496791..1497768, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apa2 is an alpha/beta protein with a core domain of a twisted eight-stranded antiparallel beta-sheet flanked by several alpha-helices, similar to the galactose-1-phosphate uridylyltransferase (GalT) members of the histidine triad (HIT) superfamily.
Title: Structures of yeast Apa2 reveal catalytic insights into a canonical AP₄A phosphorylase of the histidine triad superfamily.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP:ADP adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables bis(5'-nucleosyl)-tetraphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-nucleosyl)-tetraphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables bis(5'-nucleosyl)-tetraphosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables bis(5'-nucleosyl)-tetraphosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfate adenylyltransferase (ADP) activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate adenylyltransferase (ADP) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nucleoside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleoside catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional AP-4-A phosphorylase/ADP sulfurylase

NP_010819.1

EC 2.7.7.5

EC 2.7.7.53

Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1496791..1497768 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180838.1 → NP_010819.1 TPA: bifunctional AP-4-A phosphorylase/ADP sulfurylase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010819.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTF1, P22108

UniProtKB/TrEMBL

A6ZZB7, B3LFE1, C8Z690

Conserved Domains (1) summary

COG4360
Location:1 → 314

APA2; ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]