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    KRE28 Kre28p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852145, updated on 29-Jun-2024

    Summary

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    Gene symbol
    KRE28
    Gene description
    Kre28p
    Primary source
    FungiDB:YDR532C
    Locus tag
    YDR532C
    See related
    SGD:S000002940; AllianceGenome:SGD:S000002940; VEuPathDB:YDR532C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in kinetochore. Colocalizes with spindle pole body. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KRE28 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1499396..1500553, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene bifunctional AP-4-A phosphorylase/ADP sulfurylase Neighboring gene pantothenate kinase Neighboring gene glutathione-independent methylglyoxalase Neighboring gene Fit1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore. Roy B, et al. Open Biol, 2022 Jan. PMID 35042402, Free PMC Article
    2. C-Terminal Motifs of the MTW1 Complex Cooperatively Stabilize Outer Kinetochore Assembly in Budding Yeast. Ghodgaonkar-Steger M, et al. Cell Rep, 2020 Sep 29. PMID 32997987
    3. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. Gatbonton T, et al. PLoS Genet, 2006 Mar. PMID 16552446, Free PMC Article
    4. Cdk1 Phosphorylation of the Dam1 Complex Strengthens Kinetochore-Microtubule Attachments. Gutierrez A, et al. Curr Biol, 2020 Nov 16. PMID 32946748, Free PMC Article
    5. Phosphoregulation of Spc105 by Mps1 and PP1 regulates Bub1 localization to kinetochores. London N, et al. Curr Biol, 2012 May 22. PMID 22521787, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore.
      Title: Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore.
    2. the spc105p/kre28p complex has roles in kinetochore-microtubule binding and the spindle assembly checkpoint
      Title: Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kre28p
    NP_010821.3
    • Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1499396..1500553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180840.3 → NP_010821.3  TPA: Kre28p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010821.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTF3, Q04431, Q6Q537
      UniProtKB/TrEMBL
      A0A8H8UP61, N1P947
      Conserved Domains (1) summary
      pfam17097
      Location:1 → 382
      Kre28; Spindle pole body component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04431.1

    Gene LinkOut

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