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    IRC4 Irc4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852153, updated on 17-May-2024

    Summary

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    Gene symbol
    IRC4
    Gene description
    Irc4p
    Primary source
    FungiDB:YDR540C
    Locus tag
    YDR540C
    See related
    SGD:S000002948; AllianceGenome:SGD:S000002948; VEuPathDB:YDR540C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitotic recombination and replication-born double-strand break repair via sister chromatid exchange. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IRC4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1517136..1517675, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phenylacrylic acid decarboxylase PAD1 Neighboring gene putative phenylacrylic acid decarboxylase FDC1 Neighboring gene carbonyl reductase (NADPH-dependent) Neighboring gene seripauperin PAU10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide. Taylor JD, et al. J Mol Biol, 2016 Feb 13. PMID 26804569, Free PMC Article
    2. Use of a genome-wide approach to identify new genes that control resistance of Saccharomyces cerevisiae to ionizing radiation. Game JC, et al. Radiat Res, 2003 Jul. PMID 12816519
    3. Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid. Muñoz-Galván S, et al. PLoS Genet, 2013. PMID 23357952, Free PMC Article
    4. Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. Alvaro D, et al. PLoS Genet, 2007 Dec. PMID 18085829, Free PMC Article
    5. VID22 counteracts G-quadruplex-induced genome instability. Galati E, et al. Nucleic Acids Res, 2021 Dec 16. PMID 34871443, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication-born double-strand break repair via sister chromatid exchange IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Irc4p
    NP_010829.1
    • Protein similar to bacterial secreted DfsB proteins; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1517136..1517675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180848.1 → NP_010829.1  TPA: Irc4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTF9, Q03036
      UniProtKB/TrEMBL
      A0A6A5Q379, A6ZZC5, B3LFD3, C8Z699, G2WBR6, N1P5Z0
      Conserved Domains (1) summary
      COG4283
      Location:1 → 165
      DinB; Uncharacterized protein DinB, DUF1706 family [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03036.1

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