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    SIP2 Sip2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852664, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SIP2
    Gene description
    Sip2p
    Primary source
    FungiDB:YGL208W
    Locus tag
    YGL208W
    See related
    SGD:S000003176; AllianceGenome:SGD:S000003176; VEuPathDB:YGL208W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SPM2
    Summary
    Contributes to AMP-activated protein kinase activity. Involved in several processes, including cellular response to glucose starvation; invasive growth in response to glucose limitation; and positive regulation of pseudohyphal growth. Located in cytoplasm and plasma membrane. Part of nucleotide-activated protein kinase complex. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1) and PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SIP2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (97338..98585)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rab family GTPase YPT32 Neighboring gene Mig2p Neighboring gene chromatin-remodeling protein SPT16 Neighboring gene clathrin heavy chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the gal83 glycogen-binding domain activate the snf1/gal83 kinase pathway by a glycogen-independent mechanism. Wiatrowski HA, et al. Mol Cell Biol, 2004 Jan. PMID 14673168, Free PMC Article
    2. Yap1 accumulates in the nucleus in response to carbon stress in Saccharomyces cerevisiae. Wiatrowski HA, et al. Eukaryot Cell, 2003 Feb. PMID 12582119, Free PMC Article
    3. The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis. Zhang J, et al. Mol Microbiol, 2010 Jul. PMID 20545859
    4. Biochemical and functional studies on the regulation of the Saccharomyces cerevisiae AMPK homolog SNF1. Amodeo GA, et al. Biochem Biophys Res Commun, 2010 Jun 25. PMID 20529674, Free PMC Article
    5. Beta-subunits of the SnRK1 complexes share a common ancestral function together with expression and function specificities; physical interaction with nitrate reductase specifically occurs via AKINbeta1-subunit. Polge C, et al. Plant Physiol, 2008 Nov. PMID 18768910, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reports that NuA4 acetylation of Sip2, a regulatory beta subunit of the Snf1 complex (yeast AMP-activated protein kinase), decreases as cells age.
      Title: Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction.
    2. Sip2, but not Sip1, can take over ergosterol biosynthesis when Gal83 is deleted.
      Title: The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to AMP-activated protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in invasive growth in response to glucose limitation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein-containing complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleotide-activated protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sip2p
    NP_011307.1
    • One of three alternate beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; SIP2 has a paralog, GAL83, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      97338..98585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181073.2 → NP_011307.1  TPA: Sip2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011307.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTU7, P34164
      UniProtKB/TrEMBL
      A0A8H4C023, A6ZTY1, G2WDQ0
      Conserved Domains (2) summary
      smart01010
      Location:299 → 412
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:164 → 249
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34164.3

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