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    BCD1 Bcd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856436, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BCD1
    Official Full Name
    Bcd1p
    Primary source
    SGD:S000001082
    Locus tag
    YHR040W
    See related
    AllianceGenome:SGD:S000001082; FungiDB:YHR040W; VEuPathDB:YHR040W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables snoRNA binding activity. Involved in box C/D snoRNP assembly; ribosome biogenesis; and sno(s)RNA metabolic process. Located in cytoplasm and nucleus. Orthologous to human ZNHIT6 (zinc finger HIT-type containing 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See BCD1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (187924..189024)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene meiotic recombination directing protein Neighboring gene H(+)-transporting V1 sector ATPase subunit G Neighboring gene Srb2p Neighboring gene NADPH--hemoprotein reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity. Bragantini B, et al. Nat Commun, 2021 Mar 25. PMID 33767140, Free PMC Article
    2. A conserved Bcd1 interaction essential for box C/D snoRNP biogenesis. Khoshnevis S, et al. J Biol Chem, 2019 Nov 29. PMID 31537647, Free PMC Article
    3. Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis. Paul A, et al. RNA, 2019 Apr. PMID 30700579, Free PMC Article
    4. Functional and Structural Insights of the Zinc-Finger HIT protein family members Involved in Box C/D snoRNP Biogenesis. Bragantini B, et al. J Mol Biol, 2016 Jun 5. PMID 27139642
    5. A panoramic view of yeast noncoding RNA processing. Peng WT, et al. Cell, 2003 Jun 27. PMID 12837249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.
      Title: The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.
    2. Bcd1 is required for interactions with box C/D snoRNAs including RNA binding protein SNU13 (Snu13).
      Title: A conserved Bcd1 interaction essential for box C/D snoRNP biogenesis.
    3. Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis.
      Title: Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis.
    4. The authors identified structural features associated with the requirement of Hit1p and Bcd1p zinc finger-HIT domain for cell growth and box C/D snoRNA stability under heat stress. Altogether, the data suggest an important role of zinc finger-HIT domain could be to maintain functional folding to the rest of the protein, especially under heat stress conditions.
      Title: Functional and Structural Insights of the Zinc-Finger HIT protein family members Involved in Box C/D snoRNP Biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box C/D snoRNP assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sno(s)RNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snoRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pre-snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Bcd1p
    NP_011906.1
    • Essential protein required for the accumulation of box C/D snoRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      187924..189024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179170.1 → NP_011906.1  TPA: Bcd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011906.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKY8, P38772
      UniProtKB/TrEMBL
      A6ZSU7, B3LSG0, C7GTU0, C8ZAB1, G2WFB3, N1P3A4
      Conserved Domains (1) summary
      pfam04438
      Location:1 → 31
      zf-HIT; HIT zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38772.1

    Gene LinkOut

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